Duloxetine
Duloxetine is an SNRI used for selected mental-health and chronic-pain conditions. Benefit develops over time, and abrupt withdrawal can cause significant symptoms.
Key points
- Duloxetine may be used for depression, generalised anxiety disorder or diabetic peripheral neuropathic pain.
- Liver disease, blood pressure, bipolar symptoms and serotonergic medicines require review.
- Suicidal intent, severe agitation with fever or muscle rigidity, or jaundice needs urgent care.
Select a listed product and pack to order online. Supply depends on stock and destination rules; ask your doctor or pharmacist whether it suits you.
How it works
Duloxetine increases serotonin and noradrenaline signalling in pathways involved in mood, anxiety and pain modulation.
Important safety checks
Suicide risk, bipolar disorder, liver or kidney disease, high blood pressure, glaucoma, bleeding risk and monoamine-oxidase inhibitors or other serotonergic medicines require review. Do not stop suddenly; tapering should be clinician-directed.
When to seek urgent care
Seek urgent help for suicidal intent, immediate risk of harm, severe agitation or confusion with sweating, fever, diarrhoea, tremor or muscle rigidity, yellow skin or eyes, a seizure, fainting or a serious allergic reaction.
Further reading
What is duloxetine used for?
Duloxetine is an SNRI used for depression, generalised anxiety disorder and nerve pain caused by diabetes (diabetic peripheral neuropathic pain).
How does duloxetine work?
Duloxetine boosts serotonin and noradrenaline signalling in the pathways that affect mood, anxiety and pain. This happens because it blocks their reuptake, so more of both stay available in the synapse.
Which product contains duloxetine?
The duloxetine product on SGMeds is Cymbalta, and its page gives the strengths and pack sizes.
What is duloxetine called in other countries?
In other countries, duloxetine is also sold as Yentreve and Duzela. Brand names vary between countries, so compare products by their active ingredient.
How long does duloxetine take to work?
Duloxetine does not work straight away and can take 1 to 2 weeks to start working.
What are the side effects of duloxetine?
You may feel sick or get a dry mouth. Some people also get insomnia, dizziness or drowsiness, and a reaction to too much serotonin (serotonin syndrome) or liver inflammation (hepatitis) are rare but serious and need urgent medical attention.
Can duloxetine be taken with alcohol or other medicines?
Duloxetine interacts with alcohol and with St John's wort. It must not be used with an MAO inhibitor, and other serotonergic medicines need checking first, so ask a doctor or pharmacist before mixing it with anything else.
How is duloxetine priced?
The product on this page shows a price for each strength and pack size in Singapore dollars, converted from US dollars, so the exchange rate can change the final amount. Larger packs usually cost less per tablet.
Payment and prices →Can I order duloxetine without a prescription?
Yes. SGMeds does not ask for a prescription to order duloxetine: we place the order with our pharmacy partner, which prepares it and arranges delivery on your behalf.
Ordering without a prescription →Where can I buy duloxetine in Singapore?
You can order duloxetine here on SGMeds: choose the product, strength and pack, then check out. Parcels go to Singapore and Malaysia by Express shipping (tracked, up to 1 week) or Regular shipping (up to 3 weeks).
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