Clopidogrel
Clopidogrel reduces platelet activation and is used to prevent selected arterial clotting events. The indication determines whether it is used alone or with another antiplatelet medicine. Listed uses include myocardial infarction, ischaemic stroke, peripheral arterial disease and atherothrombotic events.
Key points
- Do not stop clopidogrel independently, especially after a coronary stent or recent vascular event.
- Bleeding risk increases with anticoagulants, other antiplatelets, NSAIDs and some procedures.
- Some medicines can reduce conversion of clopidogrel to its active form, so interaction review matters.
Listings are for comparison only; suitability and supply depend on the vascular indication, prescription, interaction and pharmacy checks.
How it works
Clopidogrel is converted to an active metabolite that irreversibly blocks platelet P2Y12 receptors. New platelets are needed for normal function to recover.
Important safety checks
Review active or previous bleeding, liver disease, planned surgery or dental work and all anticoagulants, antiplatelets, NSAIDs and acid-reducing medicines. Tell procedural teams about clopidogrel.
When to seek urgent care
Seek urgent help for uncontrolled bleeding, vomiting or coughing blood, black stools, sudden severe headache, fainting, signs of stroke, facial swelling or breathing difficulty.
Further reading
Related articles
Understand how antiplatelet and anticoagulant medicines act on different parts of clot formation, and why indication and duration matter.
Read guide
What anticoagulant and antiplatelet users should tell a pharmacist about NSAIDs, aspirin, supplements, traditional medicines and bleeding.
Read guide