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Ciclosporin

Ciclosporin suppresses selected immune responses. Systemic transplant or inflammatory-disease products and ciclosporin eye preparations have different uses and are not interchangeable.

Cyclomune

Keratoconjunctivitis Sicca

0.05 · 0.1%

Cyclomune is ciclosporin 0.05% and 0.1% eye drop emulsion for keratoconjunctivitis sicca. A calcineurin inhibitor that damps T-lymphocyte activation.

From$40.46/ bottleView

Neoral

Transplant Rejection, Rheumatoid Arthritis

25 · 100mg

Ciclosporin 25mg and 100mg soft capsules, used in the management of transplant rejection, rheumatoid arthritis and psoriasis. A calcineurin inhibitor.

From$4.82/ tabletView

Key points

  • Systemic ciclosporin requires kidney, blood-pressure, interaction and often blood-level monitoring.
  • Different systemic formulations may have different absorption and should not be switched without specialist direction.
  • Eye drops act mainly at the ocular surface and do not replace systemic transplant treatment.

Listings are for comparison only; suitability and supply depend on route, indication, specialist or clinician review, prescription and pharmacy checks.

What ciclosporin is used for

Systemic ciclosporin may be used to prevent transplant rejection or in selected severe psoriasis. Eye formulations may be used for selected keratoconjunctivitis sicca.

How it works

Ciclosporin inhibits calcineurin and reduces T-cell activation. Whole-body immune suppression is much greater with systemic treatment than with eye preparations.

Important safety checks

For systemic use, review kidney and liver function, blood pressure, infections, vaccines, cancer history, electrolytes and all medicines or supplements. Grapefruit and many prescription medicines can alter exposure.

When to seek urgent care

Seek urgent help for severe infection, confusion, seizure, chest pain, very little urine, severe weakness, facial swelling or breathing difficulty. New eye pain or sudden visual change needs prompt eye assessment.

Further reading