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Bupropion

Bupropion affects noradrenaline and dopamine signalling. Different products may be used for depression or smoking cessation, while a combination product has a separate role in weight management.

Wellbutrin SR

Tobacco Dependence, Major Depressive Disorder

150mg

Wellbutrin SR is bupropion 150mg in a modified-release tablet for tobacco dependence and major depression, a weak reuptake inhibitor of two amines.

From$1.12/ tabletView

Zyban

Smoking Cessation

150mg

Bupropion 150mg prolonged-release tablets, used in the management of smoking cessation. It antagonises the nicotinic acetylcholine receptor.

From$1.11/ tabletView

Bupron SR

Tobacco Dependence

150mg

Bupron SR is bupropion 150mg in a prolonged-release tablet, used in the management of tobacco dependence. A weak noradrenaline and dopamine reuptake inhibitor.

From$1.06/ tabletView

Wellbutrin

Major Depressive Disorder, Tobacco Dependence

150 · 300mg

Bupropion 150mg and 300mg modified-release tablets, used in the management of major depression and tobacco dependence. An aminoketone antidepressant.

From$1.06/ tabletView

Contrave

Obesity

8/90mg

Contrave pairs bupropion with naltrexone in a prolonged-release tablet for obesity, acting on the appetite and reward centres of the brain.

From$2.11/ tabletView

Key points

  • Bupropion products with different indications or release patterns are not automatically interchangeable.
  • Seizure disorders, eating disorders, abrupt alcohol or sedative withdrawal and duplicate bupropion products can make use unsafe.
  • A seizure, suicidal intent, severe agitation or a serious allergic reaction needs urgent care.

Listings are for comparison only. Suitability and supply depend on clinician and pharmacy checks, stock, destination rules and prescription requirements.

What Bupropion is used for

Bupropion may be used for depression or smoking cessation and tobacco dependence. In combination with another ingredient, it may be used for selected people with obesity.

How it works

Bupropion inhibits reuptake of noradrenaline and dopamine. The intended outcome and treatment plan depend on the formulation and indication.

Important safety checks

Seizure risk, blood pressure, bipolar symptoms, pregnancy, alcohol or sedative use, monoamine-oxidase inhibitors and all products containing bupropion require review. Mood and behaviour changes should be reported promptly, especially after starting or changing treatment.

When to seek urgent care

Seek emergency help for a seizure, suicidal intent, immediate risk of harm, severe confusion or agitation, facial swelling, breathing difficulty or a painful blistering rash.

Further reading