Skip to content

Migraine Prophylaxis

Migraine prophylaxis aims to reduce the frequency, severity or disability of future attacks. It is considered according to attack burden, acute-treatment response, medication overuse, migraine subtype and personal preference.

Inderal

Propranolol

10 · 20 · 40 · 80mg

Designed to support heart rhythm and mitigate blood pressure indicated to target migraine frequency.

From$0.34/ tabletView

Catapres

Clonidine

100mcg

Formulated to mitigate high blood pressure and designed to alleviate symptoms of hypertensive and vascular states.

From$1.00/ tabletView

Inderal La

Propranolol

40mg

Indicated to manage cardiovascular stress and anxiety symptoms by antagonizing beta-adrenergic receptors.

From$0.76/ tabletView

Elavil

Amitriptyline

10 · 25 · 50mg

Designed for effective depressive symptoms management and utilized to support mood stability in patients.

From$0.37/ tabletView

Topamax

Topiramate

25 · 50 · 100mg

Designed to support the management of epilepsy and migraine, this therapeutic agent is indicated to alleviate seizure frequency and headache severity.

From$0.68/ tabletView

Sibelium

Flunarizine

5 · 10mg

Utilized to alleviate migraine symptoms by blocking calcium influx.

From$0.60/ tabletView

Valparin

Valproic Acid

250 · 500 · 750mg

Utilized to manage seizures and stabilize mood, formulated to target neurological hyperexcitability and support better physiological function in patients.

From$3.06/ tabletView

Depakene

Valproic Acid

250 · 750mg

Formulated to manage epilepsy and bipolar disorder, this medication is indicated to support the control of seizures and is utilized to mitigate mood fluctuations.

From$2.13/ capsuleView

Key takeaways

  • Preventive medicines do not stop an attack already underway and need a planned trial before benefit can be judged.
  • Pregnancy potential, asthma, blood pressure, weight, mood and sleep can strongly affect medicine choice.
  • A headache diary helps compare attack days, severity and acute-medicine use before and after treatment.

A preventive listing cannot select a safe option or confirm migraine; diagnosis, comorbidities, interactions and reproductive plans guide prescribing.

Which medicines may be considered?

Propranolol, topiramate, amitriptyline and flunarizine act through different pathways and have different safety profiles. Valproate has major pregnancy-related risks and should not be treated as a routine option for people who could become pregnant.

How is benefit reviewed?

Review considers fewer migraine days, lower intensity, improved function and reduced acute-medicine use, not necessarily complete freedom from headache. Ineffective treatment should be reconsidered after an adequate trial within neurology care.

When to seek urgent care

Seek emergency care for a new thunderclap headache, persistent neurological deficit, seizure, confusion, fever with neck stiffness, or sudden vision loss. Suicidal thoughts or a severe medicine reaction also need immediate help.