Sofosbuvir
Sofosbuvir is a direct-acting antiviral used with other active medicines for chronic hepatitis C. The complete regimen depends on viral, liver and prior-treatment factors.
Key points
- Sofosbuvir alone is not a complete hepatitis C treatment.
- Hepatitis B status and all medicines and supplements require review before the regimen starts.
- Fainting, a very slow heartbeat, jaundice or severe abdominal swelling needs urgent assessment.
Select a listed product and pack to order online. Supply depends on stock and destination rules; ask your doctor or pharmacist whether it suits you.
How it works
Sofosbuvir is converted to an active nucleotide analogue that blocks the hepatitis C NS5B polymerase and stops viral RNA chain growth.
Important safety checks
Hepatitis B coinfection, kidney and liver function, pregnancy considerations for every regimen component and strong enzyme-inducing medicines require review. Combining certain sofosbuvir regimens with amiodarone can cause dangerous bradycardia.
When to seek urgent care
Seek urgent help for fainting, marked weakness with a very slow heartbeat, yellow skin or eyes, vomiting blood, black stools, severe abdominal swelling, confusion or a serious allergic reaction.