Sofosbuvir
Sofosbuvir is a direct-acting antiviral used with other active medicines for chronic hepatitis C. The complete regimen depends on viral, liver and prior-treatment factors.
Key points
- Sofosbuvir alone is not a complete hepatitis C treatment.
- Hepatitis B status and all medicines and supplements require review before the regimen starts.
- Fainting, a very slow heartbeat, jaundice or severe abdominal swelling needs urgent assessment.
Listings are for comparison only. Suitability and supply depend on clinician and pharmacy checks, stock, destination rules and prescription requirements.
How it works
Sofosbuvir is converted to an active nucleotide analogue that blocks the hepatitis C NS5B polymerase and stops viral RNA chain growth.
Important safety checks
Hepatitis B coinfection, kidney and liver function, pregnancy considerations for every regimen component and strong enzyme-inducing medicines require review. Combining certain sofosbuvir regimens with amiodarone can cause dangerous bradycardia.
When to seek urgent care
Seek urgent help for fainting, marked weakness with a very slow heartbeat, yellow skin or eyes, vomiting blood, black stools, severe abdominal swelling, confusion or a serious allergic reaction.