Sitagliptin

Key points

• Kidney function affects sitagliptin exposure and treatment selection.
• Low blood glucose risk rises when it is combined with insulin or a sulfonylurea.
• Severe persistent abdominal pain, facial swelling or a blistering skin reaction needs urgent care.

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How it works

Sitagliptin blocks DPP-4, prolonging incretin activity so insulin release increases and glucagon decreases when glucose is elevated.

Important safety checks

Kidney function, pancreatitis history, heart-failure symptoms, pregnancy and other diabetes medicines require review. Report severe joint pain or a new tense blistering rash. Follow the diabetes sick-day and glucose-monitoring plan.

When to seek urgent care

Seek urgent help for severe persistent upper-abdominal pain with or without vomiting, facial or throat swelling, breathing difficulty, extensive blistering skin, severe confusion, loss of consciousness or a seizure from low blood glucose.

Further reading

• Sitagliptin: MedlinePlus Drug Information
• Dipeptidyl Peptidase IV (DPP IV) Inhibitors - StatPearls - NCBI Bookshelf