Dolutegravir
Dolutegravir is an integrase inhibitor used as part of an effective combination regimen for HIV infection. Product combinations and resistance history determine whether it is suitable.
Key points
- Dolutegravir alone is not a complete HIV treatment unless used in a specifically selected complete regimen.
- Antacids, iron, calcium, magnesium and several medicines can change absorption or exposure.
- A severe rash with fever, facial swelling or jaundice needs urgent assessment.
Listings are for comparison only. Suitability and supply depend on clinician and pharmacy checks, stock, destination rules and prescription requirements.
How it works
Dolutegravir blocks HIV integrase, preventing viral DNA from being inserted into human-cell DNA and interrupting replication.
Important safety checks
Resistance history, hepatitis B status, liver disease, pregnancy and all medicines and supplements require review. Combination tablets contain other active ingredients with their own kidney, liver or pregnancy considerations. Do not stop one regimen component or restart after an interruption without the HIV team.
When to seek urgent care
Seek urgent help for a widespread rash with fever or swollen glands, facial swelling, breathing difficulty, yellow skin or eyes, dark urine, severe abdominal pain or suicidal intent.