Darunavir

Key points

• Darunavir must be taken as the exact boosted combination selected by the HIV care team.
• The booster creates extensive medicine and herbal interactions that require a complete medication review.
• A blistering rash, facial swelling, jaundice or severe abdominal pain needs urgent assessment.

Select a listed product and pack to order online. Supply depends on stock and destination rules; ask your doctor or pharmacist whether it suits you.

How it works

Darunavir blocks HIV protease, preventing newly produced viral particles from maturing. A booster slows its breakdown so effective exposure can be maintained.

Important safety checks

Resistance history, liver disease or hepatitis, sulfonamide allergy, diabetes and all prescription, over-the-counter and herbal products require review. Do not stop one regimen component or restart after an interruption without the HIV team.

When to seek urgent care

Seek urgent help for a painful or blistering rash, peeling skin, mouth or eye sores, facial swelling, breathing difficulty, yellow skin or eyes, dark urine, severe abdominal pain or marked weakness.

Further reading

• Darunavir: MedlinePlus Drug Information
• Darunavir 600 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc)