Clofazimine
Clofazimine is an antimycobacterial medicine used within specialist multidrug regimens, particularly for leprosy. It should not be used as stand-alone treatment.
Key points
- Red-brown to dark skin and body-fluid discolouration is common and can persist after treatment.
- Severe abdominal pain, vomiting or obstruction-like symptoms can reflect clofazimine accumulation in the digestive tract.
- QT prolongation risk increases with other heart-rhythm medicines or electrolyte disturbances.
Listings are for comparison only; suitability and supply depend on specialist regimen review, prescription, monitoring and pharmacy checks.
How it works
Clofazimine has antimycobacterial and anti-inflammatory effects. Combination treatment limits resistance and addresses different aspects of infection.
Important safety checks
Review heart rhythm, fainting, liver or kidney disease, digestive disorders, electrolyte problems, pregnancy and all QT-prolonging medicines. Visible skin changes can affect mental wellbeing and should be discussed openly.
When to seek urgent care
Seek urgent help for fainting, a new irregular heartbeat, severe abdominal pain, repeated vomiting, inability to pass stool or gas, suicidal thoughts, facial swelling or breathing difficulty.