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Chloramphenicol

Chloramphenicol is an Antibiotic whose clinical role depends strongly on the formulation and infection. Systemic use is restricted by rare but serious blood and bone-marrow toxicity.

Chloromycetin

Bacterial Infection, Typhoid Fever

250 · 500mg

Chloramphenicol 250mg and 500mg hard capsules, used for bacterial infection and typhoid fever. It binds the 50S ribosomal subunit in bacteria.

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Key points

  • Eye or ear preparations are not interchangeable with oral or injectable chloramphenicol, and each treats only selected bacterial infections.
  • Systemic chloramphenicol requires specialist selection and blood monitoring because it can suppress bone marrow and has been linked to aplastic anaemia.
  • Fever, sore throat, unusual bruising, bleeding, marked pallor or severe weakness needs prompt medical assessment.

Listings are for comparison and general information, not an antibiotic recommendation; suitability and supply depend on infection diagnosis, formulation, clinician and pharmacy checks and prescription requirements.

What chloramphenicol is used for

Topical formulations may be used for selected superficial bacterial infections. Systemic chloramphenicol is reserved for specific Severe Bacterial Infections when safer alternatives are unsuitable or unavailable. It does not treat viral illness.

How chloramphenicol works

Chloramphenicol binds the bacterial ribosome and inhibits protein production. This broad antibacterial activity does not remove the need to identify the infection and choose the safest effective antibiotic.

Important safety checks

Formulation, age, pregnancy or breastfeeding, liver function, blood disorders and other marrow-suppressing medicines require review. Systemic treatment may require blood counts. Do not use leftover eye or ear medicine for a new episode without confirming the diagnosis and product condition.

When to seek urgent care

Seek urgent advice for fever, persistent sore throat, mouth ulcers, unusual bruising or bleeding, marked pallor, severe tiredness or signs of a serious allergic reaction. Eye pain, light sensitivity, vision loss, injury or a chemical exposure requires urgent eye assessment rather than self-treatment.

Further reading