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Herpes Simplex

Herpes simplex virus type 1 or 2 can cause recurring oral or genital blisters and ulcers. Either type can affect either site, and infection may also be asymptomatic.

Valtrex

Valaciclovir

500 · 1000mg

Valaciclovir 500mg and 1000mg film-coated tablets, used for herpes zoster, herpes simplex and genital herpes. A prodrug converted to aciclovir.

From$2.55/ tabletView

Zovirax

Aciclovir

200 · 400 · 800mg

Aciclovir 200mg, 400mg and 800mg tablets, used for herpes simplex and varicella zoster infection. A nucleoside analogue activated by viral enzymes.

From$0.46/ tabletView

Famvir

Famciclovir

250 · 500mg

Famciclovir 250mg and 500mg film-coated tablets, used for herpes zoster, herpes simplex and genital herpes. A prodrug of penciclovir.

From$2.34/ tabletView

Key points

  • Testing a fresh lesion can confirm the virus and type when the diagnosis is uncertain.
  • Antivirals can shorten episodes or suppress recurrences but do not remove latent virus.
  • Eye symptoms, neurological features, pregnancy and reduced immunity make clinical assessment more urgent.

An antiviral listing does not confirm that a sore is herpes; site, timing, kidney function, pregnancy and immune status affect treatment.

What can reactivation look like?

Tingling, burning or itching may precede grouped blisters that become shallow ulcers. Sun exposure, illness, stress and immune suppression can precede recurrence. Other infections and inflammatory conditions can resemble herpes.

How are antivirals used?

Aciclovir, valaciclovir and famciclovir may be used for an episode or as suppression in selected cases. The plan depends on recurrence burden, transmission concerns and renal function. See antivirals for class context.

When to seek urgent care

Seek urgent care for eye pain, light sensitivity or vision change; severe headache with neck stiffness or confusion; inability to urinate; rapidly spreading lesions with marked illness; or an outbreak in a newborn or severely immunocompromised person.

Further reading