Danazol
Danazol alters pituitary and sex-hormone signalling. It has specialist uses but can cause androgenic, liver and thrombotic adverse effects and must not be used during pregnancy.
Key points
- Danazol is reserved for selected cases where its expected benefit outweighs substantial hormonal and metabolic risks.
- Pregnancy prevention, liver function, clot risk and interacting medicines require review.
- Chest pain, sudden breathlessness, jaundice or a severe new headache with neurological symptoms needs urgent care.
Listings are for comparison only. Suitability and supply depend on clinician and pharmacy checks, stock, destination rules and prescription requirements.
What Danazol is used for
Danazol may be used for selected endometriosis or prevention of attacks in hereditary angioedema when a specialist finds it appropriate.
How it works
Danazol suppresses gonadotropin release and has weak androgenic effects. Its action in hereditary angioedema increases production of C1 inhibitor.
Important safety checks
Pregnancy, breastfeeding, unexplained genital bleeding, liver or kidney disease, clot history, migraine and lipid changes require review. Warfarin and several other medicines can interact. Voice deepening or other androgenic changes may not fully reverse.
When to seek urgent care
Seek urgent help for chest pain, sudden breathlessness, coughing blood, one-sided leg swelling, yellow skin or eyes, severe abdominal pain, or a sudden severe headache with visual, speech or strength changes.