Carbidopa
Carbidopa is used with levodopa in Parkinson’s disease. It has little useful antiparkinsonian effect alone but allows more levodopa to reach the brain and reduces some peripheral adverse effects.
Sinemet CR
Parkinson's Disease
25/100mg
Sinemet CR is carbidopa with levodopa 25/100mg in a modified-release tablet for Parkinson's disease, spreading the dose across a longer period.
Key points
- Carbidopa must be considered as part of a specific levodopa combination, not as an independent treatment.
- Different release forms and ingredient ratios are not automatically interchangeable.
- Fever with severe stiffness or confusion, sudden sleep episodes or dangerous hallucinations needs urgent assessment.
Select a listed product and pack to order online. Supply depends on stock and destination rules; ask your doctor or pharmacist whether it suits you.
How it works
Carbidopa blocks conversion of levodopa to dopamine outside the brain. This increases levodopa delivery to the brain and reduces peripheral nausea and cardiovascular effects.
Important safety checks
The exact combination, release form, meal timing and other Parkinson’s medicines require review. Treatment can cause involuntary movements, low blood pressure, hallucinations, sudden sleepiness and impulse-control changes. Do not stop the combination abruptly.
When to seek urgent care
Seek urgent help for fever with severe stiffness or confusion, collapse, a sudden sleep episode that causes danger, severe hallucinations, chest pain, vomiting blood or suicidal intent.
Further reading
What is carbidopa used for?
Carbidopa is used with levodopa in Parkinson's disease. It has little useful effect on its own, and it must always be part of a specific levodopa combination rather than a treatment by itself.
How does carbidopa work?
Carbidopa blocks the conversion of levodopa to dopamine outside the brain. This lets more levodopa reach the brain and reduces nausea and heart-related effects elsewhere in the body.
Which products contain carbidopa?
Products containing carbidopa on SGMeds include Sinemet, Sinemet CR and Stalevo. Compare their forms, strengths and pack sizes.
How long does carbidopa take to work?
Carbidopa typically begins to act within 30 to 60 minutes. The effect lasts about 3 to 6 hours.
What are the side effects of carbidopa?
Common effects include uncontrolled movements (dyskinesia), nausea, dizziness and dry mouth. Low blood pressure on standing, confusion and insomnia can also occur, and hallucinations or a rare reaction with high fever and stiff muscles (neuroleptic malignant syndrome) need immediate medical attention.
Who should not take carbidopa?
Do not use it if you are allergic to any of its ingredients, have narrow-angle glaucoma, or take a non-selective MAO inhibitor. Ask a doctor or pharmacist if you are unsure whether it is suitable for you.
How is carbidopa priced?
Each product on this page shows a price for each strength and pack size in Singapore dollars, converted from US dollars, so the exchange rate can change the final amount. Larger packs usually cost less per tablet.
Payment and prices →Do I need a prescription for carbidopa in Singapore?
No. SGMeds does not ask for a prescription to order carbidopa: we place the order with our pharmacy partner, which prepares it and arranges delivery on your behalf.
Ordering without a prescription →Where can I buy carbidopa in Singapore?
You can order carbidopa here on SGMeds: choose the product, strength and pack, then check out. Parcels go to Singapore and Malaysia by Express shipping (tracked, up to 1 week) or Regular shipping (up to 3 weeks).
How ordering works →