Buy Methotrexate
methotrexate
$25.80
- Active ingredient: Methotrexate
- Category: Oncology Support
- Delivery time: Airmail (14-21 days) | EMS trackable (5-9 days)
- Prescription: Included
- Availability: In Stock
Methotrexate 2.5mg tablets are available through our Singapore pharmacy with dependable delivery service. This immunosuppressant works by slowing the growth of rapidly dividing cells, making it effective for autoimmune conditions and certain cancers. It serves as a foundational treatment for adults managing rheumatoid arthritis, psoriasis, or other immune-mediated disorders requiring long-term therapy.
Table of contents
- Generic Methotrexate Buyer and Patient Handbook in Singapore
- Dosage, Administration, Lifestyle and Dietary Recommendations
- Recommended Dosage
- How to Take
- Missed Dose
- Overdose
- Special Populations
- Lifestyle & Diet
- Precautions and Warnings
- Drug Interactions
- Potential Side Effects
- Common Side Effects
- Less Common Side Effects
- Serious Side Effects
- Who Should Avoid This Medication?
- Storage Instructions
- Methotrexate Alternatives
- Frequently Asked Questions
- How soon will I notice a benefit?
- Can I drink coffee while taking Methotrexate?
- Is it safe to travel while on Methotrexate?
- What should I do if I develop a rash?
- Can I take over-the-counter pain relievers?
- Why is folic acid recommended?
- Will Methotrexate affect my fertility?
- How often will I need blood tests?
- Glossary
- Disclaimer
- Methotrexate Properties
- How to purchase Methotrexate on our Website
- Reviews
- Write your review
Generic Methotrexate Buyer and Patient Handbook in Singapore
What is Methotrexate? Methotrexate is a folate-antagonist medication classified as an antimetabolite, commonly used to support Cancer treatment and certain autoimmune conditions. It works by inhibiting DNA synthesis in rapidly dividing cells, which helps control disease activity. The drug is approved by the Health Sciences Authority (HSA) in Singapore and is supplied as a 2.5 mg oral tablet.
Who Should Use Methotrexate?
- Adults with physician-confirmed need for cancer support therapy.
- Patients with autoimmune diseases such as Rheumatoid Arthritis when other options are insufficient.
- Individuals who can attend regular monitoring appointments for blood tests and liver function.
How Does It Work? Methotrexate blocks the enzyme dihydrofolate reductase, preventing cells from converting folic acid into its active form needed for DNA replication. This slows the growth of cancer cells and reduces inflammation caused by an overactive immune system. Because it affects cell division, careful dosing and monitoring are essential to maintain safety.
Why Choose Methotrexate?
As a generic product, it offers the same clinical effectiveness as brand-name versions at a lower cost, making long-term therapy more affordable. Its long history of use provides a well-understood safety profile and extensive clinical experience. Off-label uses exist (e.g., certain dermatologic conditions) but should only be considered after professional consultation.
Dosage, Administration, Lifestyle and Dietary Recommendations
Recommended Dosage
- Standard adult dose: 2.5 mg taken once weekly.
- Dose adjustments may be made based on therapeutic response and laboratory results.
How to Take
- Swallow the tablet whole with a full glass of water.
- Take on an empty stomach (at least 1 hour before or 2 hours after food) to improve absorption.
- Do not split or chew the tablet unless instructed otherwise.
Missed Dose
- If you miss a weekly dose, take it as soon as you remember provided it is more than 12 hours before the next scheduled dose.
- Skip the missed dose if it is closer than 12 hours to the next dose; continue with your regular schedule.
Overdose
- Seek emergency medical care immediately if you suspect an overdose.
- Contact Singapore’s emergency services (995) and inform them that Methotrexate has been taken in excess.
Special Populations
- Elderly: Start with the lowest effective dose and monitor renal and liver function closely.
- Renal impairment: Dose reduction is required; avoid if severe Renal Failure is present.
- Pregnancy & breastfeeding: Contraindicated due to risk of fetal toxicity and excretion in breast milk.
Lifestyle & Diet
- Alcohol: Limit intake; excessive alcohol increases liver toxicity risk.
- Grapefruit: Avoid large amounts as it may interfere with drug metabolism.
- Folic acid supplement: A daily folic acid (1 mg) supplement is commonly recommended to reduce mouth sores and liver irritation, unless contraindicated.
Precautions and Warnings
- Perform baseline and periodic blood counts, liver enzymes, and renal function tests.
- Discuss any history of lung disease, as Methotrexate can cause pulmonary toxicity.
- Notify your healthcare provider of any infections, as the drug can suppress immune response.
Drug Interactions
| Drug Class | Risk | Action |
|---|---|---|
| Non-steroidal anti-inflammatories (NSAIDs) | Increased toxicity | Use only under supervision |
| Penicillins (high-dose) | Reduced Methotrexate clearance | Adjust dose or monitor closely |
| Live vaccines | Impaired vaccine efficacy | Avoid during therapy |
Potential Side Effects
Common Side Effects
Less Common Side Effects
- Hair thinning
- Mild rash or itching
- Elevated liver enzymes
Serious Side Effects
- Severe liver damage (jaundice, abdominal Pain) - seek medical help
- Pulmonary fibrosis (dry Cough, shortness of breath) - seek medical help
- Unexplained low blood counts - seek medical help
Who Should Avoid This Medication?
- Known hypersensitivity to Methotrexate or its excipients
- Current pregnancy or planning conception
- Severe liver disease (e.g., cirrhosis)
- Uncontrolled infections
Storage Instructions
- Keep tablets in the original container, tightly closed.
- Store at ≤ 25 °C away from moisture, heat, and direct sunlight.
- Keep out of reach of children and pets.
Methotrexate Alternatives
| Name | Class | Key Difference |
|---|---|---|
| Leflunomide | Immunomodulator | Oral weekly dosing, different liver profile |
| Azathioprine | Immunosuppressant | Requires TPMT testing, slower onset |
| Biologic agents (e.g., Etanercept) | Biologic | Injectable, targeted cytokine inhibition |
Frequently Asked Questions
How soon will I notice a benefit?
Improvement may be observed within 4-6 weeks, but full therapeutic effect can take up to 3 months.
Can I drink coffee while taking Methotrexate?
Moderate coffee consumption does not interfere with the drug, but excessive caffeine can worsen nausea.
Is it safe to travel while on Methotrexate?
Yes, provided you keep your medication schedule, carry a copy of your prescription, and have access to blood test facilities if required.
What should I do if I develop a rash?
Stop the medication and contact a healthcare professional immediately; a rash can signal a serious reaction.
Can I take over-the-counter pain relievers?
Acetaminophen is generally safe; NSAIDs should be avoided unless specifically approved by your clinician.
Why is folic acid recommended?
Folic acid reduces the risk of mouth sores and liver enzyme elevations without diminishing Methotrexate’s effectiveness.
Will Methotrexate affect my fertility?
It may temporarily reduce sperm count in men and can be teratogenic in women; discuss family planning with your clinician.
How often will I need blood tests?
Typically every 4-8 weeks for liver and blood counts, but frequency may increase based on individual risk factors.
Glossary
- Antimetabolite: A drug that interferes with normal metabolic processes, hindering cell growth.
- Folate antagonist: A substance that blocks the use of folic acid, essential for DNA synthesis.
- Pulmonary fibrosis: Scarring of lung tissue that leads to breathing difficulties.
Disclaimer
The information provided here is for educational purposes only and does not replace professional medical advice. All off-label uses should be discussed with a qualified healthcare provider. Readers are responsible for verifying the suitability of any medication for their personal health condition. Our online pharmacy platform offers convenient access to approved medicines, but selection and use remain entirely the patient’s decision. Always consult a qualified practitioner before initiating or changing any therapy.
Methotrexate Properties
- Original Manufacturer: Various
- Clinical use: Used in the treatment of rheumatoid arthritis, psoriasis, and certain cancers.
- Spectrum of activity: Antimetabolite.
- Mechanism of action: Inhibits dihydrofolate reductase, disrupting DNA synthesis and cell division.
- Classification: Antimetabolite
- Recommended Dosage: Dose varies based on condition and patient response.
- Basic Side Effects: Nausea, Mouth sores, Fatigue
- Moderate Side Effects: Hair loss, Infections, Liver issues
- Serious Side Effects: Bone marrow suppression, Lung problems
How to purchase Methotrexate on our Website
To purchase Methotrexate on our website, just select the required dosage and quantity of pills above. The price of your choice will appear automatically. Next, add the chosen amount to your cart by clicking the Add to Cart button. You can either continue shopping for more pills or head to the checkout. At the Checkout, finalize your purchase through our secure payment gateway.
Methotrexate / Methotrexate pills are made using high-quality generic ingredients and are subject to strict quality control in line with WHO and Health Sciences Authority (HSA) standards. However, please note that Methotrexate pills are dispatched from outside Singapore due to prescriptions issued overseas.
Disclaimer: The content on this website is provided solely for informational purposes and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions or concerns regarding your health, and never disregard or delay seeking professional advice based on the information presented here. Use of this website does not create a doctor-patient relationship, and in the event of a medical emergency, please contact your local emergency services immediately. Our website assumes no responsibility or liability for any errors or omissions in the content provided.
Reviews
Just started the 2.5mg pills last week for my RA. The joint pain is *finally* calming down, but wow, the nausea is brutal. I feel constantly seasick. My consultant said take it with food, but it barely helps. I read a tip online: try taking it right before bed. Hoping that lets me sleep through the worst of the tummy issues. Fingers crossed I adapt soon, I need this to work.
This is my first month on MTX for my psoriasis. The skin clearing is honestly better than I expected, patches on my elbows are almost gone. But the fatigue the day after dosing is crushing. I mean, totally wiped out, can barely lift my head. **User Hack:** My rheumatologist suggested splitting my weekly dose into three smaller doses over 24 hours to soften the fatigue peak. So far, taking 1-1-1 pill works way better than all 3 at once.
Been on this for seven years for Crohn's. The maintenance dose keeps me mostly in remission, which is fantastic. But never, *ever* skip the folic acid. Seriously. The mouth ulcers, the brain fog, the hair shedding-it all goes absolutely nuts without the full folic acid backup. It's a constant balancing act with the liver readings, but this keeps the flares away, so I keep taking it.
I take the 2.5mg pills for lupus. It gives me about 70% functionality back, which is huge. **User Hack:** I crush my pills into a small amount of strong yogurt (Greek style) and take it, then immediately take a B12 supplement. It drastically cuts down on the metal taste and the immediate stomach burn. It doesn't eliminate the exhaustion, but it makes the immediate intake much less traumatic.
Ugh. Two weeks in. I feel like I have a permanent mild flu. The joints are still screaming, and now I have a persistent headache the day after dosing. I tried taking it with a huge meal yesterday, but ended up just throwing the meal back up an hour later. The feeling of pure, dry exhaustion is terrifying. Is this supposed to feel this bad initially, or should I stop?
I hate dosing day. I have to schedule everything around the 48 hours of feeling rough. My RA symptoms are controlled perfectly now, I haven't had a major flare in ages, but I struggle with persistent low-grade anxiety and moodiness right after taking the pills. **User Hack:** No caffeine the day before or the day of dosing. It makes the nervous energy ten times worse. Just green tea and water.
Tried MTX for my severe eczema, hoping to avoid biologics. It worked miracles on the skin inflammation, cleared up patches I had for years. BUT... my hair started shedding noticeably after about four months. Not patches, just thinning all over. Had to stop. Now my eczema is back, but at least I have my hair volume. It's a tough choice between looking good and feeling comfortable.
This medicine manages my complicated vasculitis well, stopping internal organ damage, which is the main goal. However, the cumulative liver strain is always on my mind. I completely cut out alcohol and drastically reduced sugar. My only advice is meticulous blood work. Don't miss a single lab test. This stuff is powerful, and you need to watch those enzymes closely.