Buy Leukeran
leukeran
$93.50
- Active ingredient: Chlorambucil
- Category: Oncology Support
- Delivery time: Airmail (14-21 days) | EMS trackable (5-9 days)
- Prescription: Included
- Availability: In Stock
Leukeran (Chlorambucil) 2mg and 5mg tablets are available to order from our Singapore pharmacy with reliable delivery. This chemotherapy medication works by interfering with DNA replication in rapidly dividing cancer cells, preventing their growth and spread. Its alkylating action specifically targets lymphoid malignancies by disrupting cell division processes. It is a crucial treatment for individuals with chronic lymphocytic leukemia or Hodgkin lymphoma who require targeted chemotherapy under specialist supervision.
Table of contents
- Leukeran (Chlorambucil) Buyer and Patient Handbook in Singapore
- What is Leukeran?
- Who Should Use Leukeran?
- How Does It Work?
- Why Choose Leukeran?
- Dosage, Administration, Lifestyle and Dietary Recommendations
- Recommended Dosage
- How to Take
- Missed Dose
- Overdose
- Special Populations
- Lifestyle & Diet
- Precautions and Warnings
- Drug Interactions
- Potential Side Effects
- Common Side Effects
- Less Common Side Effects
- Serious Side Effects
- Who Should Avoid This Medication?
- Storage Instructions
- Leukeran Alternatives
- Frequently Asked Questions
- How quickly will I notice an effect from Leukeran?
- Can I take Leukeran with my regular vitamins or supplements?
- Is it safe to drink coffee while on Leukeran?
- What should I do if I develop a fever?
- Will Leukeran affect my ability to work or drive?
- Can I receive a flu shot while on Leukeran?
- How often will I need blood tests?
- Is there a risk of long-term secondary cancers?
- Can I stop taking Leukeran if I feel better?
- How does Leukeran compare to generic chlorambucil?
- Glossary
- Disclaimer
- Leukeran Properties
- Leukeran Drug Class
- Leukeran Connected Conditions
- How to purchase Leukeran on our Website
- Reviews
- Write your review
Leukeran (Chlorambucil) Buyer and Patient Handbook in Singapore
What is Leukeran?
Leukeran is the brand name for chlorambucil, an oral alkylating agent used in the treatment of certain blood-cancer disorders. It belongs to the alkylating-agent class and is indicated for chronic lymphocytic leukaemia (CLL) and selected Lymphomas. In Singapore the product is approved by the Health Sciences Authority and is supplied as a tablet.
Who Should Use Leukeran?
- Adults diagnosed with chronic lymphocytic leukaemia or low-grade non-Hodgkin Lymphoma.
- Patients whose disease is responsive to alkylating therapy as determined by their healthcare team.
- Individuals with adequate liver and kidney function to metabolise and clear the drug.
How Does It Work?
Leukeran works by adding an alkyl group to DNA strands, which prevents Cancer cells from replicating their genetic material correctly. Think of it as inserting a “speed-bump” into the DNA road-map, causing the malignant cells to stall and die. While it targets rapidly dividing cells, normal blood-forming cells can also be affected, which is why monitoring is essential.
Why Choose Leukeran?
Leukeran offers a convenient once-daily oral tablet, avoiding the need for frequent hospital infusions. For many patients the tablet form provides greater flexibility and reduced travel time compared with intravenous regimens. Generic chlorambucil is also available, giving comparable efficacy at a lower cost.
Dosage, Administration, Lifestyle and Dietary Recommendations
Recommended Dosage
The usual adult dose ranges from 2 mg to 5 mg taken once daily, adjusted according to disease stage, body weight and tolerability. Dose modifications are made by a qualified clinician based on blood counts and organ function. Always follow the specific regimen prescribed for you.
How to Take
- Swallow the tablet whole with a full glass of water.
- The dose may be taken with or without food; however, taking it with a meal can reduce stomach upset.
- Do not crush or chew the tablet, as this may alter absorption.
Missed Dose
If you remember a missed dose within 12 hours, take it immediately. If it has been longer than 12 hours, skip the forgotten dose and resume the regular schedule. Do not double-dose to make up for a missed tablet.
Overdose
In case of suspected overdose, seek emergency medical help or contact the Singapore Poison Centre (+65 6896 3333) immediately. Symptoms may include severe Nausea, Vomiting, low blood counts or confusion. Prompt treatment can mitigate serious complications.
Special Populations
- Elderly: May require a lower starting dose and closer blood-count monitoring.
- Renal or hepatic impairment: Dose reduction is recommended; clinicians will assess kidney and liver tests before prescribing.
- Pregnancy & breastfeeding: Chlorambucil is contraindicated due to risk of fetal harm and passage into breast milk. Effective contraception is required for women of child-bearing age.
Lifestyle & Diet
- Avoid grapefruit and grapefruit juice, which can increase drug levels and raise toxicity risk.
- Maintain a balanced diet rich in protein, fruits and vegetables to support marrow recovery.
- Limit alcohol consumption, as it can worsen liver stress and haemorrhagic tendencies.
- Stay hydrated and report any persistent fever, sore throat or unusual bruising promptly.
Precautions and Warnings
Leukeran can cause bone-marrow suppression, leading to lowered white-blood cells, platelets and red cells. Regular full-blood-count tests are required before starting therapy and throughout treatment. Infection risk is heightened; practice good hand hygiene and avoid close contact with individuals who have active infections. Women should use reliable contraception throughout treatment and for at least six months after the last dose. If you develop severe stomach Pain, persistent vomiting, or signs of bleeding, contact your healthcare provider without delay.
Drug Interactions
| Drug Class | Risk | Action |
|---|---|---|
| Anticoagulants (e.g., warfarin) | Increased bleeding | Monitor INR frequently; dose adjust |
| Live vaccines | Reduced vaccine efficacy / infection risk | Avoid during treatment; use inactivated vaccines only |
| CYP2C19 inhibitors (e.g., fluconazole) | Elevated chlorambucil levels | Dose reduction or increased monitoring |
Potential Side Effects
Common Side Effects
- Nausea or mild vomiting
- Fatigue or weakness
- Mild diarrhoea
- Low white-blood-cell count (neutropenia)
Less Common Side Effects
- Hair thinning or loss
- Mild rash or itching
- Elevated liver enzymes
- Low platelet count (thrombocytopenia)
Serious Side Effects
- Severe neutropenia: fever, chills, sore throat - call a doctor immediately.
- Profuse bleeding: gums bleeding, blood in urine or stool - seek urgent care.
- Signs of secondary cancers (e.g., bladder, skin): unexplained lumps or persistent skin changes - report promptly.
Who Should Avoid This Medication?
- Patients with a known hypersensitivity to chlorambucil or any tablet excipients.
- Individuals with severe bone-marrow failure (e.g., aplastic anaemia).
- Pregnant or breastfeeding women.
- Patients receiving high-dose radiation therapy to the abdomen (increased toxicity risk).
Storage Instructions
- Keep tablets below 30 °C, away from direct sunlight.
- Store in the original container tightly closed to protect from moisture.
- Keep out of reach of children and pets.
- Do not use after the expiry date printed on the pack.
Leukeran Alternatives
| Name | Class | Key Difference |
|---|---|---|
| Cyclophosphamide | Alkylating agent | Higher potency, given intravenously |
| Fludarabine | Purine analogue | More immunosuppressive, IV route |
| Bendamustine | Alkylating/antimetabolite | Combined mechanisms, used in refractory cases |
Frequently Asked Questions
How quickly will I notice an effect from Leukeran?
Most patients see a gradual decline in lymphocyte counts within 4-8 weeks, but clinical response varies and may take several months.
Can I take Leukeran with my regular vitamins or supplements?
Yes, most over-the-counter vitamins are safe, but avoid high-dose antioxidants such as vitamin E above 400 IU daily, as they may interfere with chemotherapy efficacy.
Is it safe to drink coffee while on Leukeran?
Moderate coffee intake (up to three cups per day) is generally safe, but excessive caffeine can increase dehydration risk, especially if nausea is present.
What should I do if I develop a fever?
A fever may signal infection due to lowered white cells; contact your healthcare provider promptly and do not self-medicate with over-the-counter analgesics without advice.
Will Leukeran affect my ability to work or drive?
Most patients maintain normal daily activities, but extreme fatigue or dizziness may necessitate temporary adjustments; discuss with your clinician if you feel unsafe driving.
Can I receive a flu shot while on Leukeran?
An inactivated flu vaccine is recommended and safe; avoid live-attenuated nasal spray vaccines.
How often will I need blood tests?
Typically, a full-blood-count is performed weekly for the first month, then every two to four weeks once stable.
Is there a risk of long-term secondary cancers?
Chlorambucil carries a small increased risk of secondary malignancies such as bladder cancer; regular monitoring and lifestyle measures (e.g., adequate hydration) help mitigate this risk.
Can I stop taking Leukeran if I feel better?
Do not discontinue treatment without medical guidance; abrupt cessation can lead to disease progression.
How does Leukeran compare to generic chlorambucil?
The generic version contains the same active ingredient, dosage form and efficacy, but may be offered at a lower price point.
Glossary
- Alkylating agent: A drug class that attaches alkyl groups to DNA, disrupting cell replication.
- Neutropenia: An abnormally low count of neutrophils, a type of white blood cell vital for fighting infections.
- Thrombocytopenia: A reduced platelet count that impairs normal blood clotting.
Disclaimer
The information provided here is for general educational purposes only and does not replace professional medical advice. Off-label uses, dosage adjustments and treatment decisions should be made in consultation with a qualified healthcare provider. Our online pharmacy service supplies medications in compliance with Singapore regulations; users remain responsible for ensuring suitability of any medication for their personal health condition. Always consult your doctor or pharmacist before starting, stopping, or altering any medication.
Leukeran Properties
- Original Manufacturer: GlaxoSmithKline
- Clinical use: Used in the treatment of chronic lymphocytic leukemia and certain lymphomas.
- Spectrum of activity: Alkylating agent.
- Mechanism of action: Interferes with DNA replication by alkylating the DNA, leading to cell death.
- Classification: Alkylating agent
- Recommended Dosage: Dose varies based on condition and patient response.
- Basic Side Effects: Nausea, Vomiting, Fatigue
- Moderate Side Effects: Mouth sores, Hair loss, Infections
- Serious Side Effects: Bone marrow suppression, Cancer
Leukeran Drug Class
Leukeran Connected Conditions
How to purchase Leukeran on our Website
To purchase Leukeran | Chlorambucil on our website, just select the required dosage and quantity of pills above. The price of your choice will appear automatically. Next, add the chosen amount to your cart by clicking the Add to Cart button. You can either continue shopping for more pills or head to the checkout. At the Checkout, finalize your purchase through our secure payment gateway.
Leukeran / Chlorambucil pills are made using high-quality generic ingredients and are subject to strict quality control in line with WHO and Health Sciences Authority (HSA) standards. However, please note that Leukeran pills are dispatched from outside Singapore due to prescriptions issued overseas.
Disclaimer: The content on this website is provided solely for informational purposes and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions or concerns regarding your health, and never disregard or delay seeking professional advice based on the information presented here. Use of this website does not create a doctor-patient relationship, and in the event of a medical emergency, please contact your local emergency services immediately. Our website assumes no responsibility or liability for any errors or omissions in the content provided.
Reviews
Managed to control the lymphoma spread, which is the main thing. But god, the fatigue. It’s not just tired; it’s bone-deep exhaustion by 3 PM. Long-term hack: I take my 5mg dose right before bed with a small, fatty snack. It seems to minimize the midday crash. Blood counts fluctuate wildly, so prepare for those check-ups.
Just started the 2mg for my polycythemia vera. First week was horrible nausea, I threw up twice. Doctor said that was normal for Chlorambucil. Now on week three, the nausea is fading, but the mouth ulcers are *brutal*. I look like I’ve been sucking on sandpaper. Someone on a forum suggested taking it with a glass of cold milk instead of water. That really helped coat things.
Been on Leukeran for 18 months for my Waldenström’s. It definitely works to keep the IgM levels down. Major downside: the cognitive fog. It feels like my IQ dropped 10 points. Important warning: Do not drink any alcohol AT ALL while on this. Even one small beer gives me a migraine that lasts two days. Stick to decaf during the day.
My vasculitis flared up badly, and this was prescribed. The skin cleared up impressively fast, zero rash now. Positive on that front. However, the insomnia is relentless. Four hours of broken sleep is the best I get. My 'user hack' is to try and split the 2mg pill (use a proper splitter!) and take half in the morning, half lunch. Helped balance the nervous energy.
I hate this pill. It worked for my specific autoimmune disease but the effects on my liver enzymes were unacceptable after six months. Switched to something else. While taking it, the most annoying side effect was the hair loss. Not clumps, but overall thinning. If you are female and worried, watch your vitamin D and B levels closely; it seems to accelerate deficiencies.
Chlorambucil is a slow burn. It takes time to see results, don't expect anything major the first month. I take 5mg daily. My platelets have stabilized finally. The big issue for me is the taste. It leaves a metallic, chemical taste in my mouth for hours. Pro tip: immediately chew strong mint gum afterwards to mask the lingering taste. Don't skip doses because that just makes the nausea return worse the next day.
First time on chemo, very nervous. Started 2mg Leukeran for my chronic lymphocytic leukemia (CLL). The first three days I had terrible acid reflux and burning throat, almost like a heartburn that wouldn't quit. Pharmacist advised taking an OTC antacid 30 minutes before the Leukeran. It worked, mostly. Still dealing with frequent low-grade fever spells. It's worrying.
Used this for years and it kept my inflammatory condition locked down way better than steroids ever did. Reliable, but you have to respect the fatigue cycle. I found that combining my daily dose with a high-protein breakfast minimized stomach upset and provided a slow energy release that helped fight the inevitable 4 PM slump. It's manageable if you plan your day around it.