Buy Tofranil
tofranil
$18.36
- Active ingredient: Imipramine
- Category: Mental Health
- Delivery time: Airmail (14-21 days) | EMS trackable (5-9 days)
- Prescription: Included
- Availability: In Stock
Tofranil (Imipramine) 25mg, 50mg, and 75mg tablets are available to order from our Singapore pharmacy with dependable delivery. This tricyclic antidepressant helps restore chemical balance in the brain by increasing levels of norepinephrine and serotonin, neurotransmitters that regulate mood. Beyond depression, it's also used for bedwetting in children and certain anxiety disorders. Tofranil provides a well-established treatment option for adults managing major depressive disorder who may benefit from its dual-action mechanism and proven efficacy in clinical use over decades.
Table of contents
- Tofranil (Imipramine) Buyer and Patient Handbook in Singapore
- What is Tofranil?
- Who Should Use Tofranil?
- How Does It Work?
- Why Choose Tofranil?
- Dosage, Administration, Lifestyle and Dietary Recommendations
- Recommended Dosage
- How to Take
- Missed Dose
- Overdose
- Special Populations
- Lifestyle & Diet
- Precautions and Warnings
- Drug Interactions
- Potential Side Effects
- Common Side Effects
- Less Common Side Effects
- Serious Side Effects
- Who Should Avoid This Medication?
- Storage Instructions
- Tofranil Alternatives
- Frequently Asked Questions
- How long does it take for Tofranil to start working?
- Can I take Tofranil with coffee?
- What should I do if I feel drowsy during the day?
- Is it safe to drive while on Tofranil?
- Can Tofranil cause weight changes?
- Will Tofranil interact with over-the-counter cold medicines?
- How should I taper off Tofranil?
- What does “serotonin syndrome” feel like?
- Glossary
- Disclaimer
- Tofranil Properties
- Tofranil Drug Class
- Tofranil Connected Conditions
- How to order Tofranil from our Online Pharmacy
- Reviews
- Write your review
Tofranil (Imipramine) Buyer and Patient Handbook in Singapore
What is Tofranil?
Tofranil is a tricyclic antidepressant (TCA) used primarily to treat Major Depressive Disorder and certain Anxiety conditions. It belongs to the antidepressant class and is approved by the Health Sciences Authority (HSA) for adult use in Singapore. The medication is supplied as oral pills in strengths of 25 mg, 50 mg, and 75 mg.
Who Should Use Tofranil?
- Adults diagnosed with major depressive disorder
- Patients with chronic dysthymia or mixed anxiety-depressive states
- Individuals for whom first-line treatments (e.g., SSRIs) were ineffective or not tolerated
How Does It Work?
Tofranil increases the levels of serotonin and norepinephrine in the brain by blocking their re-uptake into nerve cells, which helps improve mood and anxiety symptoms. Think of it as dimming the “noise” of low mood and allowing clearer mental signals to pass. It is not habit-forming, but abrupt discontinuation can cause withdrawal-type effects, so tapering is recommended under professional guidance.
Why Choose Tofranil?
As a generic version of the original imipramine molecule, Tofranil offers the same therapeutic effect at a lower cost than many brand-name options. It has a long history of use with a well-characterised safety profile, making it a reliable choice for clinicians and patients seeking proven efficacy.
Dosage, Administration, Lifestyle and Dietary Recommendations
Recommended Dosage
- Initial: 25 mg once daily, usually in the evening
- Typical maintenance: 50 mg-75 mg daily, divided or taken once depending on response
How to Take
- Swallow the tablet whole with a full glass of water.
- Preferably take in the evening to reduce daytime Drowsiness.
- Do not crush or chew unless instructed otherwise.
Missed Dose
- If you remember within 6 hours, take the missed tablet.
- If it’s later, skip it and continue with the next scheduled dose.
Overdose
- Call the Singapore Poison Centre (24 hours) at 180-222-5555 immediately.
- Seek emergency care; symptoms may include rapid heartbeat, severe drowsiness, or Seizures.
Special Populations
- Elderly: Start at 25 mg; monitor for orthostatic hypotension.
- Renal/hepatic impairment: No dosage change needed, but observe for increased side-effects.
- Pregnancy & lactation: Use only if the benefit outweighs risk; discuss with a healthcare professional.
Lifestyle & Diet
- Avoid alcohol; it can intensify Sedation and increase the risk of side-effects.
- Grapefruit juice may raise imipramine levels-limit consumption.
- Maintain regular sleep-wake patterns; abrupt changes may affect mood stability.
Precautions and Warnings
- Monitor for signs of increased suicidal thoughts, especially during the first few weeks.
- Use caution when driving or operating machinery until you know how the drug affects you.
- Report any signs of irregular heartbeat, severe constipation, or urinary retention promptly.
Drug Interactions
| Drug Class | Risk | Action |
|---|---|---|
| MAO inhibitors | Serotonin syndrome, hypertensive crisis | Stop MAOI ≥ 14 days before starting Tofranil |
| SSRIs / SNRIs | Increased serotonin toxicity | Consider dose reduction or alternative therapy |
| Anticholinergic agents | Exacerbated dry mouth, constipation | Monitor symptoms; adjust dose if needed |
Potential Side Effects
Common Side Effects
- Dry mouth
- Drowsiness or mild sedation
- Constipation
- Blurred vision
Less Common Side Effects
- Weight gain or loss
- Dizziness on standing (orthostatic hypotension)
- Sweating
Serious Side Effects
- Irregular heartbeat or palpitations - seek medical help
- Severe allergic reaction (rash, swelling, difficulty breathing) - call emergency services
- Signs of serotonin syndrome (Agitation, rapid fever, muscle rigidity) - immediate medical attention required
Who Should Avoid This Medication?
- Patients with recent myocardial infarction or uncontrolled heart disease
- Those with a known hypersensitivity to imipramine or other TCAs
- Individuals currently on MAO inhibitors without appropriate wash-out period
Storage Instructions
- Keep the bottle tightly closed at room temperature (15 °C-30 °C).
- Store away from direct sunlight and moisture.
- Keep out of reach of children and pets.
Tofranil Alternatives
| Name | Class | Key Difference |
|---|---|---|
| Sertraline | SSRI | Fewer anticholinergic effects |
| Venlafaxine | SNRI | More activating, less sedating |
| Amitriptyline | TCA (older) | Longer half-life, higher cardiotoxicity risk |
Frequently Asked Questions
How long does it take for Tofranil to start working?
Most patients notice an improvement in mood after 2-4 weeks, though full benefits may require 6-8 weeks of consistent use.
Can I take Tofranil with coffee?
Moderate coffee intake is generally safe, but excessive caffeine may worsen anxiety or Insomnia in some users.
What should I do if I feel drowsy during the day?
Try taking the dose at night; if drowsiness persists, discuss a possible dose adjustment with your healthcare professional.
Is it safe to drive while on Tofranil?
Avoid driving or operating heavy machinery until you know how the medication affects you, especially during the first week.
Can Tofranil cause weight changes?
Weight fluctuations are possible; maintain a balanced diet and monitor any significant changes.
Will Tofranil interact with over-the-counter cold medicines?
Some antihistamines have anticholinergic properties that can intensify dry mouth and constipation-consult a pharmacist before combining.
How should I taper off Tofranil?
A gradual reduction (e.g., decreasing 25 mg every 1-2 weeks) is recommended to minimise withdrawal symptoms; follow a plan set by your clinician.
What does “serotonin syndrome” feel like?
Symptoms include agitation, high fever, rapid heartbeat, and muscle rigidity. Seek emergency care immediately if they occur.
Glossary
- Tricyclic antidepressant (TCA): A class of older antidepressants that affect serotonin and norepinephrine pathways.
- Serotonin syndrome: A potentially life-threatening reaction to excess serotonin activity.
- Anticholinergic: Drug effects that block acetylcholine, leading to dry mouth, constipation, and blurred vision.
Disclaimer
The information presented here is for general educational purposes and reflects current knowledge about Tofranil (imipramine). It does not constitute medical advice, and off-label use should only be considered after professional consultation. Readers are responsible for verifying the suitability of this medication for their own health situation and should always discuss treatment options with a qualified healthcare provider. Our platform offers convenient access to licensed pharmacies in Singapore; all transactions are subject to HSA regulations.
Tofranil Properties
- Original Manufacturer: Novartis
- Clinical use: Major depressive disorder and enuresis
- Spectrum of activity: Broad-spectrum
- Mechanism of action: Inhibits the reuptake of serotonin and norepinephrine
- Classification: Tricyclic antidepressant
- Recommended Dosage: 75-150 mg daily
- Basic Side Effects: Dry mouth, Constipation, Drowsiness
- Moderate Side Effects: Orthostatic hypotension, Urinary retention
- Serious Side Effects: Cardiac arrhythmias, Seizures
Tofranil Drug Class
Tofranil Connected Conditions
How to order Tofranil from our Online Pharmacy
To order Tofranil | Imipramine on our online pharmacy, all you need to do is select the required dosage and quantity of pills above. The cost of the selected pack will appear automatically. Next, add the chosen amount to your cart by clicking the Add to Cart button. You can either continue shopping for more medications or head to the checkout. At the Checkout, finalize your purchase through our secure payment gateway.
Tofranil / Imipramine pills are made using high-quality generic ingredients and are subject to strict quality control in line with WHO and Health Sciences Authority (HSA) standards. However, please note that Tofranil pills are dispatched from outside Singapore due to prescriptions issued overseas.
Disclaimer: The content on this website is provided solely for informational purposes and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions or concerns regarding your health, and never disregard or delay seeking professional advice based on the information presented here. Use of this website does not create a doctor-patient relationship, and in the event of a medical emergency, please contact your local emergency services immediately. Our website assumes no responsibility or liability for any errors or omissions in the content provided.
Reviews
Just started the 25mg for nerve pain, not depression. It's only been a week. My mouth feels like a desert. Seriously, I wake up needing water. The sedation is intense; I take it at 8 PM and I'm basically useless by 9:30. Hoping the body adapts soon. Doc said four weeks until the pain relief really kicks in. Right now, I just feel fuzzy and thirsty.
Been on 75mg for two years for severe generalized anxiety. It works, honestly, it quieted the constant hum of worry almost instantly. *But* the weight gain is real. I put on 8kg in the first six months even with gym effort. Long-term user tip: If you get dizzy standing up (orthostatic hypotension), make sure you increase your salt intake slightly in the morning. It helps manage the blood pressure drops.
Mixed feelings. It stabilized my mood swings from bipolar type II much better than the SSRIs they tried before. Complete game changer for that. However, the sweating is insane. I feel like I'm constantly sticky, especially in this Bangkok heat, even sitting indoors. I tried splitting the 50mg dose into 25 morning/25 evening, but the insomnia got worse. Back to 50mg at night and living with the sweat.
I take it for bedwetting-enuresis-not depression. The 50mg is effective, no accidents since month three. The trade-off? Constipation that makes you want to cry. Absolute concrete. The pharmacist suggested using psyllium husk fiber every single day, without fail. Don't skip it, seriously. It takes a few months to dial in the water intake with the fiber, but it's necessary to avoid pain.
Week two on 50mg. My doc moved me up from 25mg. I feel jittery sometimes, almost like too much coffee, even though I cut caffeine completely. The worst part is the horrible metallic taste, it's constant. Someone told me to chew sugar-free gum right after taking the pill to mask it, and that provides about 30 minutes of relief. Definitely struggling with the side effects right now, feeling discouraged.
Been on 75mg for 18 months for chronic migraines. It significantly reduced the frequency from 15 a month to about 4. I'll take it. One big side effect is the sexual dysfunction; libido basically zero. My tip for dry mouth relief: Biotene mouthwash saved my life. Standard water wasn't cutting it. Also, try taking the pill with a full glass of whole milk, not just water, it seems to slow the absorption slightly, reducing the initial rush.
Using this (Imipramine) for severe panic disorder, 75mg daily. It's effective at blocking the panic attacks, but the foggy brain feeling lingers. I feel like my memory is worse-finding words is harder than before. Long-term hack: To lessen the brain fog, I make sure to separate my daytime doses (I take 50mg morning, 25mg afternoon). Also, NO alcohol whatsoever. Even one beer makes the confusion unbearable.
It works perfectly for my neuropathic pain stemming from diabetes. It numbs the constant tingling and burning in my feet, 50mg at night. It unfortunately did absolutely nothing for my depression, which is why they first prescribed it. My mood is still low, but at least my feet don't hurt. My primary care physician is now adding a separate med for my mood. So, good for pain, useless for mental health, for me anyway.