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Naltrexone

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naltrexone

$58.70

Naltrexone hydrochloride 50mg tablets are available through our Singapore-based pharmacy with discreet delivery options. This opioid antagonist works by blocking the euphoric effects of alcohol and opioids, reducing cravings and preventing relapse. It is an evidence-based treatment for adults in recovery from alcohol or opioid dependence who are committed to maintaining sobriety through pharmacological support.

Table of contents

Naltrexone (Naltrexone Hydrochloride) Buyer and Patient Handbook - Singapore

What is Naltrexone?

Naltrexone is an opioid-receptor antagonist used primarily to reduce alcohol cravings and to help maintain abstinence from opioid-dependent substances. It belongs to the antagonist class of medications and is approved by both the FDA and Health Sciences Authority (HSA) of Singapore. The drug is supplied as a 50 mg oral tablet.

Who Should Use Naltrexone?

  • Adults (≥18 years) seeking to curb alcohol use disorder.
  • Individuals who have completed opioid detoxification and aim to prevent relapse.
  • Patients motivated to engage in counseling or behavioral therapy alongside medication.

How Does It Work?

Naltrexone binds tightly to mu-opioid receptors in the brain, blocking the rewarding effects of alcohol and opioids. By preventing these receptors from being activated, the medication reduces the urge to drink or use opioids. It does not produce euphoria or a “high,” and therefore carries a low abuse potential.

Why Choose Naltrexone?

  • Proven efficacy: Clinical trials show a significant reduction in heavy-drinking days and opioid relapse rates.
  • Convenient dosing: A single 50 mg tablet taken once daily.
  • Generic availability: Cost-effective compared with brand-only options, while meeting the same bio-equivalence standards.

Dosage, Administration, Lifestyle and Dietary Recommendations

  • Standard dose: 50 mg taken orally once daily, preferably in the morning.

How to Take

  • Swallow the tablet whole with a full glass of water.
  • Can be taken with or without food, but a consistent routine helps maintain steady blood levels.

Missed Dose

  • If you miss a dose, take it as soon as you remember once.
  • If it is almost time for the next dose, skip the missed one and resume the regular schedule. Do not double-dose.

Overdose

  • Symptoms may include Nausea, Vomiting, dizziness, or rapid heart rate.
  • Seek immediate medical attention at the nearest hospital or call Singapore’s emergency number 995.

Special Populations

  • Elderly: Start with a lower dose (e.g., 25 mg) under medical supervision.
  • Liver impairment: Use with caution; dose adjustment may be required.
  • Pregnancy & breastfeeding: Only if the potential benefit outweighs the risk; discuss with a healthcare professional.

Lifestyle & Diet

  • Avoid drinking alcohol while on Naltrexone, as the medication is intended to reduce its effects.
  • No known food interactions, but grapefruit can affect metabolism of some drugs; inform your clinician if you consume large amounts.
  • Maintain regular physical activity and attend counseling sessions for optimal results.

Precautions and Warnings

  • Do not start Naltrexone until you are opioid-free for at least 7-10 days to avoid precipitated withdrawal.
  • May cause liver enzyme elevation; periodic liver function tests are recommended.
  • Monitor for signs of Depression or suicidal thoughts, especially during the initial weeks of therapy.

Drug Interactions

Drug Class Interaction Risk Recommended Action
Opioid analgesics (e.g., morphine, oxycodone) Blocked analgesic effect Use only if medically necessary; consider alternative pain relief
Hepatotoxic agents (e.g., isoniazid) Increased liver strain Monitor liver enzymes closely
CYP3A4 inhibitors (e.g., ketoconazole) Higher Naltrexone levels Dose adjustment may be needed

Potential Side Effects

Common Side Effects

  • Nausea
  • Headache
  • Fatigue
  • Dizziness

Less Common Side Effects

Serious Side Effects

  • Hepatotoxicity (jaundice, dark urine) - seek medical help immediately
  • Severe allergic reaction (hives, swelling, breathing difficulty) - call 995

Who Should Avoid This Medication?

  • Active opioid users (risk of precipitated withdrawal)
  • Severe hepatic impairment (e.g., cirrhosis)
  • Known hypersensitivity to Naltrexone or any tablet excipients

Storage Instructions

  • Keep tablets in the original container, tightly closed.
  • Store at 15 °C-30 °C (room temperature), away from direct sunlight and moisture.
  • Keep out of reach of children and pets.

Naltrexone Alternatives

Name Class Key Difference
Acamprosate Antagonist (glutamate) Works on brain-chemical pathways, not opioid receptors
Disulfiram Aldehyde dehydrogenase inhibitor Causes unpleasant reaction when alcohol is consumed
Baclofen GABA-B agonist Muscle relaxant with off-label use for alcohol dependence

Frequently Asked Questions

How long does it take for Naltrexone to start reducing cravings?

Most patients notice a reduction in cravings within 1-2 weeks, though the full effect may take up to a month of consistent use.

Can I drink alcohol while taking Naltrexone?

Naltrexone blocks the pleasurable effects of alcohol, but drinking defeats the purpose of therapy and can still cause health harms. Abstinence is recommended.

Will Naltrexone cause drowsiness that affects my work?

Drowsiness is reported by some users, especially during the first few days. If it interferes with daily activities, discuss dose timing with your clinician.

Is it safe to combine Naltrexone with antidepressants?

Generally safe, but both can affect liver enzymes. Regular liver monitoring is advised.

What should I do if I experience severe nausea?

Try taking the tablet with food and a larger glass of water. If nausea persists or is disabling, contact a healthcare professional.

Can I stop Naltrexone abruptly?

Yes, it can be discontinued without tapering. However, stopping may increase the risk of relapse; discuss a plan with your clinician.

Does Naltrexone affect blood sugar or diabetes control?

No direct effect has been documented, but any medication can influence overall health; keep your regular Diabetes checks.

Is Naltrexone covered by Medisave or private insurance in Singapore?

Coverage varies by insurer. Verify with your provider whether the medication is listed under outpatient benefits.

Glossary

  • Opioid receptor antagonist: A drug that blocks receptors that usually respond to opioid substances, preventing their effects.
  • Precipitated withdrawal: Sudden onset of withdrawal symptoms caused by an antagonist displacing opioids from receptors.
  • Bioequivalence: Demonstrates that a generic product delivers the same amount of active ingredient into the bloodstream as the brand version.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Off-label uses are not discussed; any such considerations require a qualified health professional. Our service offers medication information and ordering assistance but does not prescribe or dispense drugs directly. Always consult a qualified healthcare provider before starting, stopping, or changing any medication regimen.

Naltrexone Properties

  • Clinical use: Alcohol and opioid dependence
  • Spectrum of activity: Broad-spectrum
  • Mechanism of action: Blocks opioid receptors, reducing the effects of opioids and alcohol
  • Classification: Opioid antagonist
  • Recommended Dosage: 50 mg daily for alcohol dependence, 50-100 mg daily for opioid dependence
  • Basic Side Effects: Headache, Nausea, Dizziness
  • Moderate Side Effects: Constipation, Sleep disturbances
  • Serious Side Effects: Liver damage, Severe allergic reactions

How to purchase Naltrexone on our Online Drugstore

To purchase Naltrexone | Naltrexone Hydrochloride on our website, just select the required dosage and quantity of pills above. The price of your choice will appear automatically. Next, add the chosen amount to your cart by clicking the Add to Cart button. You can either continue shopping for more pills or head to the checkout. At the Checkout, finalize your purchase through our secure payment gateway.

Naltrexone / Naltrexone-hydrochloride pills are made using high-quality generic ingredients and are subject to strict quality control in line with WHO and Health Sciences Authority (HSA) standards. However, please note that Naltrexone pills are dispatched from outside Singapore due to prescriptions issued overseas.

Disclaimer: The content on this website is provided solely for informational purposes and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions or concerns regarding your health, and never disregard or delay seeking professional advice based on the information presented here. Use of this website does not create a doctor-patient relationship, and in the event of a medical emergency, please contact your local emergency services immediately. Our website assumes no responsibility or liability for any errors or omissions in the content provided.

Reviews

4.73/198
Naltrexone

First week on 50mg for alcohol craving. Honestly, the nausea is brutal. I have to take it right after dinner, otherwise I spend the next three hours dry-heaving. The good news is, the mental noise about needing a drink has definitely quieted down. It's like the volume dropped from 10 to 3. Pro tip: Seriously, eat something heavy before popping this. Don't try it on an empty stomach unless you enjoy misery.

Amelia F. Kuala Lumpur, Malaysia

This drug is weird. On one hand, zero cravings. That part is magic. On the other hand, the insomnia is almost unbearable. I can only get maybe five hours of very fragmented sleep now. If I take it too late, I just lie there with racing thoughts. I'm trying the "user hack" of splitting the 50mg pill and taking half in the morning and half in the afternoon. So far, the afternoon dose seems to hit me harder. Still figuring it out.

Wei L. Singapore City, Singapore

I've been on Naltrexone for eight months now for chronic pain management (POTS/EDS off-label, low dose LDN eventually escalated to 50mg). It works better than anything else for the day-to-day dull ache, but the dreams are INSANE. Super vivid, sometimes nightmares, sometimes just exhausting epic movies playing in my head. I have to make sure I don't drink any caffeine past noon or it intensifies the dream-state weirdness. Definitely worth the weird dreams to feel less pain though.

Maria R. Manila, Philippines

Long-timer here. Initially took it for opioid dependence recovery. The first two weeks felt like having a massive flu-chills, sweats, deep bone ache. I nearly quit. But once that rough patch passed, the clarity was incredible. I still sometimes get that spaced-out, slightly dizzy feeling about an hour after taking the 50mg pill. My workaround is always taking it with a large glass of milk and some ginger candy. It cuts the stomach flip right out. Been clean for two years thanks to this.

Putu C. Denpasar, Indonesia

I started Naltrexone for weight management, thinking it would kill the food noise. It did. For about three weeks. Now, the constant hunger is back, but the weird side effect of not feeling joy persists. Everything is just meh. I still take it because I'm afraid of the cravings coming back full force, even though I'm barely getting a benefit now. Anyone else feeling emotionally flat? I miss feeling properly happy or sad.

Sopita P. Bangkok, Thailand

Listen up: always take it immediately before bed, not upon waking. When I first started the 50mg dose, I took it in the morning and felt completely useless-fatigue, brain fog, zero motivation. Switched to bedtime dose per my online support group's advice, and now I just sleep through the worst of the side effects, mostly. Still wake up thirsty enough to drink the ocean, but it's manageable. It has definitely erased the need to self-medicate with wine nightly.

Joko S. Jakarta, Indonesia

The cognitive side effects are real. Sometimes I feel like I'm struggling to find simple words, especially in the afternoon. It feels like my brain is moving in slow motion. If I have a big presentation or a meeting, I try to take the pill later in the day, skipping the morning dose entirely. It's a tough balancing act because missing a dose makes the cravings loud again, but the drug makes me feel dumb. It works, but at what cost to my career?

Li Na P. Ipoh, Malaysia

I'm a newbie, only two weeks in at 25mg (split from the 50). This drug is intense. The diarrhea hits hard about an hour after the dose. I've noticed if I eat a piece of banana or some plain rice with it, it lessens the stomach upset slightly. The mental calm is great, I feel less impulsive. But damn, the gastro issues make planning life hard. It's a chemical straightjacket for the impulse demons, which is good, but my digestive system hates it.

Rey M. Cebu City, Philippines

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