Nortriptyline

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nortriptyline

$47.40

Nortriptyline hydrochloride 25mg tablets are available from our Singapore pharmacy with nationwide delivery. This tricyclic antidepressant works by increasing levels of norepinephrine and serotonin in the brain, improving mood and also providing relief from chronic nerve pain. It is suitable for adults dealing with depression or neuropathic pain conditions who need comprehensive symptom management.

Table of contents

Nortriptyline (Nortriptyline Hydrochloride) Buyer and Patient Handbook in Singapore

Nortriptyline (Nortriptyline Hydrochloride) is a tricyclic antidepressant commonly prescribed for depressive disorders in Singapore. It belongs to the class of tricyclic antidepressants (TCAs) and is available as oral tablets. The medication is approved by the Health Sciences Authority (HSA) and conforms to local regulatory standards.

What is Nortriptyline?

Nortriptyline is a TCA that treats Major Depressive Disorder and can also help with certain Chronic Pain conditions. It works by increasing the levels of norepinephrine and serotonin in the brain, which improves mood and emotional balance. The drug is supplied in 25 mg tablets for oral use.

Who Should Use Nortriptyline?

  • Adults diagnosed with moderate to severe Depression
  • Patients who have not responded well to newer antidepressants
  • Individuals whose physician deems a TCA appropriate after evaluating medical history

How Does It Work?

Nortriptyline blocks the re-uptake of the neurotransmitters norepinephrine and serotonin, allowing them to remain active longer in the synaptic cleft. This modulation helps restore normal mood signalling pathways. Because it can affect heart rhythm, it should be used under medical supervision, especially in people with cardiac disease.

Why Choose Nortriptyline?

  • Cost-effective: Generic version offers substantial savings compared with brand-only options.
  • Proven efficacy: Long-standing clinical data support its use for depression when other agents are insufficient.
  • Versatility: Can be prescribed for Neuropathic Pain or Migraine prophylaxis if clinically indicated.

Dosage, Administration, Lifestyle and Dietary Recommendations

  • Typical starting dose: 25 mg once daily (usually in the evening).
  • Dose may be increased gradually, based on response and tolerability, up to 150 mg per day.

How to Take

  • Swallow the tablet whole with a full glass of water.
  • Taking it in the evening can reduce daytime Drowsiness.
  • Food does not markedly affect absorption, but a light snack may lessen stomach upset.

Missed Dose

  • If you remember the dose within 12 hours, take it immediately.
  • If more than 12 hours have passed, skip the missed tablet and resume the regular schedule.
  • Do not double-dose to catch up.

Overdose

  • Seek emergency medical care immediately if you suspect an overdose.
  • Call Singapore’s emergency number 995 and provide the amount taken.
  • Keep the medication out of reach of children to prevent accidental ingestion.

Special Populations

  • Elderly: Start at a lower dose (10-15 mg) and monitor for Sedation or orthostatic hypotension.
  • Renal or hepatic impairment: Dose adjustment may be required; consult a healthcare professional.
  • Pregnancy & lactation: Use only if benefits outweigh potential risks, after professional advice.

Lifestyle & Diet

  • Avoid vigorous tasks (e.g., operating heavy machinery) until you know how the drug affects you.
  • Grapefruit can increase blood levels; limit consumption.
  • Alcohol may intensify sedation-drink moderately or avoid if possible.

Precautions and Warnings

  • Cardiac risk: Nortriptyline can prolong the QT interval; a baseline ECG is advisable for patients with heart disease.
  • Suicidal thoughts: Monitor mood closely during the first few weeks of therapy.
  • Seizure threshold: Use cautiously in individuals with a history of Seizures.
  • Drug-induced hyponatremia: Watch for sudden fluid retention or confusion, especially in older adults.

Drug Interactions

Drug Class Interaction Risk Recommended Action
MAO inhibitors Severe (serotonin syndrome) Discontinue one drug; wait ≥ 14 days
SSRIs / SNRIs Moderate (serotonin excess) Dose reduction or close monitoring
Anticholinergics High (excessive dry mouth, urinary retention) Consider alternative therapy

Potential Side Effects

Common Side Effects

  • Drowsiness or Fatigue
  • Dry mouth
  • Constipation

Less Common Side Effects

  • Blurred vision
  • Weight gain
  • Sweating

Serious Side Effects

  • Rapid or irregular heartbeat
  • Severe dizziness or fainting
  • Signs of an allergic reaction (rash, swelling, difficulty breathing) - seek immediate medical help

Who Should Avoid This Medication?

  • Individuals with known hypersensitivity to nortriptyline or any TCA component
  • Patients with recent myocardial infarction or uncontrolled cardiac arrhythmias
  • Those taking monoamine oxidase inhibitors within the past 14 days

Storage Instructions

  • Keep tablets in the original container, tightly closed.
  • Store at room temperature (15-30 °C), away from light and moisture.
  • Keep out of reach of children and pets.

Nortriptyline Alternatives

Name Class Key Difference
Sertraline SSRI Lower cardiac risk, different side-effect profile
Amitriptyline TCA Higher potency, more anticholinergic effects
Venlafaxine SNRI Often better tolerated for anxiety symptoms

Frequently Asked Questions

How long does it take to feel the effect?

Most patients notice mood improvement within 2-4 weeks, though full benefits may take up to 8 weeks.

Can I drink coffee while taking Nortriptyline?

Yes, moderate coffee intake is acceptable, but excessive caffeine may increase Anxiety or Insomnia.

Is it safe to combine Nortriptyline with over-the-counter sleep aids?

Only if a healthcare professional approves; many OTC sleep aids contain antihistamines that can increase sedation.

What should I do if I feel unusually sleepy during the day?

Report the symptom promptly; your dose may need adjustment or a switch to a once-daily evening regimen.

Can Nortriptyline cause weight changes?

Weight gain is a known side effect; maintaining a balanced diet and regular activity can help manage it.

Is it okay to stop the medication abruptly?

No-tapering under professional guidance reduces the risk of withdrawal symptoms such as irritability or flu-like effects.

Does Nortriptyline affect sexual function?

It can cause decreased libido or erectile difficulties in some individuals; discuss alternatives if this becomes problematic.

Will this medication interfere with my blood pressure medication?

Potential interactions exist, especially with drugs affecting heart rhythm; always inform your prescriber of all current medicines.

Glossary

  • Tricyclic antidepressant (TCA): A class of older antidepressants that work by inhibiting re-uptake of certain neurotransmitters.
  • QT interval: A measurement on an ECG that reflects the time taken for the heart’s electrical system to recharge; prolongation can predispose to arrhythmias.
  • Hyponatremia: Low sodium level in the blood, which can cause confusion, headache, and seizures.

Disclaimer

The information provided is for general educational purposes only and does not replace professional medical advice. Off-label uses should be discussed with a qualified healthcare provider. Readers are responsible for verifying the suitability of Nortriptyline for their own health condition and for following local regulations when accessing medication through our online pharmacy platform. Always consult a qualified health professional before starting, changing, or stopping any medication.

Nortriptyline Properties

  • Original Manufacturer: Novartis
  • Clinical use: Antidepressant
  • Spectrum of activity: Treats depression and manages chronic pain conditions
  • Mechanism of action: Inhibits the reuptake of serotonin and norepinephrine in the brain
  • Classification: Tricyclic antidepressant
  • Recommended Dosage: Typically starts at 25 mg daily, increased gradually to 75-100 mg
  • Basic Side Effects: Dry mouth, Constipation, Drowsiness
  • Moderate Side Effects: Increased heart rate, Blurred vision, Weight gain
  • Serious Side Effects: Serotonin syndrome, Heart arrhythmias, Seizures

How to purchase Nortriptyline on our Website

To purchase Nortriptyline | Nortriptyline Hydrochloride on our website, just select the required dosage and quantity of pills above. The price of your choice will appear automatically. Next, add the chosen amount to your cart by clicking the Add to Cart button. You can either continue shopping for more pills or head to the checkout. At the Checkout, finalize your purchase through our secure payment gateway.

Nortriptyline / Nortriptyline-hydrochloride pills are made using high-quality generic ingredients and are subject to strict quality control in line with WHO and Health Sciences Authority (HSA) standards. However, please note that Nortriptyline pills are dispatched from outside Singapore due to prescriptions issued overseas.

Disclaimer: The content on this website is provided solely for informational purposes and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions or concerns regarding your health, and never disregard or delay seeking professional advice based on the information presented here. Use of this website does not create a doctor-patient relationship, and in the event of a medical emergency, please contact your local emergency services immediately. Our website assumes no responsibility or liability for any errors or omissions in the content provided.

Reviews

4.77/177
Nortriptyline

Started (25mg) three weeks ago for chronic nerve pain, specifically burning feet. The sedative effect is intense, truly knocks me out, which is good for sleep, but I wake up feeling like I've been hit by a truck. The key hack? Take it exactly 10-12 hours before you need to wake up. Tried taking it later, and the morning grogginess was unbearable. I'm drinking water like crazy because the dry mouth is 24/7. Still waiting for the pain relief to fully kick in.

Aisha K. Kuala Lumpur, Malaysia

This is my fifth month on Nortriptyline for tension headaches and mild anxiety. It stabilized my mood way better than the SSRI I was on previously, zero sexual side effects, which is a massive win. Downside? The weight gain is real. About 5kg in four months without changing my diet much. I now split the 25mg pill and take half in the early evening and the other half right before bed. It seems to temper the morning daze slightly.

Joko A. Jakarta, Indonesia

Using this for migraine prevention after failing on Topamax. It actually reduced the frequency from 15 days a month to maybe six, so A+ there. However, coming off caffeine is mandatory. If I try to have even half a cup of black coffee after taking my night dose, I get major heart palpitations and anxiety spikes. Stick to plain water and herbal tea past 4 PM. It's a decent trade-off, but losing my morning bulletproof coffee habit has been rough.

Piyawat C. Bangkok, Thailand

Just started using it for insomnia linked to past trauma. Day 5. The first couple of nights, I was out cold, dreamless sleep. Amazing. Now I am experiencing severe constipation. I read online that fiber supplements don't really cut it with this class of meds; you need powerful stool softeners. I'll try Milk of Magnesia tonight. I hope the sleep benefits stick around long enough for me to adapt to the GI issues.

Maria L. Cebu City, Philippines

Been on 25mg for nearly two years now for generalized anxiety that manifested as IBS. It completely calmed my gut down; I haven't had a major flare-up in months. My main concern is the feeling of cognitive dulling-it's like my quick wit vanished. I mix things up, forget common words sometimes. I try to counteract it by doing serious brain puzzles in the morning. The feeling is manageable, but I often wonder if I'm operating at 90%.

Wei H. Singapore

Prescribed it for Fibromyalgia pain, but it didn't touch the deep muscle aches. What it did do was wipe out the restless leg syndrome I didn't even know was treatable. So, complex results. The sweating at night is terrible, though. I wake up absolutely drenched, even with the AC blasting. Pro tip: always keep a spare t-shirt next to the bed and maybe invest in cooling bedding. The pain relief for RLS makes me stick with it.

Rina S. Surabaya, Indonesia

Tried this specific TCA because my doctor said it was the most weight-neutral of the class. That was inaccurate for me; I gained rapidly, almost 7kg in three months. I also developed bad peripheral vision blurring in low light, which is really unnerving, especially when driving home. It helped my chronic phantom limb pain significantly, so I'm sticking with it, but the constant visual check-ups are annoying. Hydration is critical on this med.

Sophea M. Johor Bahru, Malaysia

Switched to Nortriptyline (25mg) from Amitriptyline because the "hangover effect" on the higher dose was impossible. This one is dramatically better for daytime function, though it takes a solid two weeks for the side effects to settle. I had crazy initial dizziness and heart racing. To avoid the morning dizziness, I sit on the edge of the bed for five full minutes before standing up. Seriously, don't jump right out of bed, or you'll stumble.

Benito D. Manila, Philippines

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