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Jentadueto Xr (Linagliptin; Metformin Hydrochloride) Buyer and Patient Handbook in Singapore

What is Jentadueto Xr?

Jentadueto Xr is a fixed-dose combination tablet that contains the DPP-4 inhibitor linagliptin (2.5 mg) and the biguanide Metformin hydrochloride (100 mg). It belongs to the diabetes therapeutic class and is indicated for adults with Type 2 Diabetes mellitus to improve blood-glucose control, especially when metformin alone does not achieve target levels. The product carries approvals from the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA) and Singapore’s Health Sciences Authority (HSA). It is supplied as a standard oral pill.

Who Should Use Jentadueto Xr?

• Adults (≥ 18 years) diagnosed with type 2 diabetes
• Patients whose blood glucose remains above target despite metformin monotherapy
• Individuals seeking to simplify their regimen by reducing pill burden
• Those with preserved renal function (eGFR ≥ 30 mL/min/1.73 m²) and no history of lactic acidosis

How Does It Work?

Linagliptin blocks the enzyme dipeptidyl-peptidase-4, which normally degrades the incretin hormones GLP-1 and GIP. Higher incretin levels stimulate the pancreas to release more insulin after meals and suppress glucagon, lowering post-prandial glucose. Metformin primarily reduces hepatic glucose production and improves peripheral insulin sensitivity, helping to lower fasting glucose. Together, the two agents address different pathways of glucose regulation, providing a more balanced glycaemic effect. There is no abuse potential associated with either component.

Why Choose Jentadueto Xr?

• Convenience: One tablet replaces separate linagliptin and metformin pills, supporting better adherence.
• Proven quality: The brand formulation meets stringent bio-equivalence standards and is manufactured under Good Manufacturing Practice (GMP).
• Cost-effectiveness: While a branded product, it may be covered by local insurance schemes; generic equivalents (linagliptin + metformin) are also available for price-sensitive patients.
• Off-label use (e.g., in gestational diabetes) is not recommended without specialist guidance.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 1 tablet (2.5 mg/100 mg) taken once daily with the main meal of the day.

How to Take

1. Swallow the tablet whole; do not crush or chew.
2. Take it with a full glass of water (≈ 200 mL).
3. Administer with breakfast, lunch, or dinner - consistency helps minimise gastrointestinal upset.

Missed Dose

• If you remember within 12 hours, take the missed tablet with the next meal.
• If more than 12 hours have passed, skip it and resume the regular schedule; do not double-dose.

Overdose

• Seek immediate medical attention or call Singapore’s emergency number 995.
• Symptoms may include severe Nausea, Vomiting, abdominal Pain, or hypoglycaemia.

Special Populations

• Elderly: Start at the recommended dose; monitor renal function regularly.
• Renal impairment: Use only if eGFR ≥ 30 mL/min/1.73 m²; dose adjustment not required for linagliptin but metformin may need reduction.
• Hepatic disease: Avoid if there is severe hepatic insufficiency.
• Pregnancy & lactation: Not recommended unless the benefit outweighs risk; discuss with a specialist.

Lifestyle & Diet

• Avoid excessive alcohol ( > 14 units/week) as it raises the risk of lactic acidosis.
• Maintain a balanced diet rich in fibre, whole grains, and lean protein.
• Grapefruit has minimal interaction but large quantities of other citrus fruits may affect metformin absorption; keep intake moderate.
• Stay hydrated; dehydration can increase metformin-related risks.

Precautions and Warnings

• Lactic acidosis: Rare but serious; watch for unexplained Muscle Pain, breathing difficulty, or abdominal discomfort.
• Hypoglycaemia: More likely if combined with sulfonylureas or insulin; monitor blood glucose closely.
• Renal monitoring: Check eGFR at baseline, then at least annually.
• Hepatic monitoring: Assess liver enzymes if there is a history of liver disease.
• Allergy: Discontinue immediately if you develop rash, itching, or swelling of the face/tongue.

Drug Interactions

Potential Side Effects

Common Side Effects

• Nausea
• Diarrhoea
• Stomach upset
• Headache

Less Common Side Effects

• Upper Respiratory Tract Infection
• Dizziness
• Metallic taste

Serious Side Effects

• Lactic acidosis: severe abdominal pain, rapid breathing, lethargy - call emergency services.
• Severe hypersensitivity: rash, blisters, facial swelling - stop medication and seek medical help.
• Pancreatitis: persistent upper-abdominal pain with vomiting - seek immediate attention.

Who Should Avoid This Medication?

• Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²)
• Individuals with hepatitis or cirrhosis of the liver
• History of lactic acidosis while on metformin
• Known hypersensitivity to linagliptin, metformin, or any excipients
• Uncontrolled type 1 diabetes or diabetic ketoacidosis

Storage Instructions

• Keep below 30 °C; avoid damp or humid places.
• Store in the original blister pack to protect from moisture.
• Keep out of reach of children and pets.
• Do not refrigerate or freeze.

Jentadueto Xr Alternatives

Frequently Asked Questions

How quickly will Jentadueto Xr lower my blood sugar?

Most patients observe a modest reduction in HbA1c (≈ .6-.9 %) after 12 weeks of consistent use.

Can I take Jentadueto Xr if I’m on insulin?

Yes, but dose adjustments may be necessary to avoid hypoglycaemia; regular glucose monitoring is essential.

Is it safe to drink coffee while on this medication?

Moderate caffeine intake (1-2 cups daily) does not interfere with the drug’s action.

Will I need regular blood tests?

Baseline kidney and liver function tests are recommended, then yearly or as advised by your healthcare professional.

Does the tablet cause weight gain?

Neither linagliptin nor metformin typically cause weight gain; some patients even experience modest weight loss.

What should I do if I experience persistent diarrhoea?

Contact a healthcare provider; they may suggest dose titration or switching to an extended-release formulation.

Can I use this medication during my fasting month (Ramadan)?

Yes, but take the tablet with the pre-dawn (Suhoor) or sunset (Iftar) meal to minimise gastrointestinal upset.

Is there any risk of hypoglycaemia if I skip a meal?

If you miss a meal, do not skip the tablet; instead, monitor glucose closely and consider a small snack.

Glossary

• DPP-4 inhibitor: A drug that blocks the enzyme responsible for breaking down incretin hormones, enhancing insulin release after meals.
• Metformin: The first-line oral agent for type 2 diabetes that lowers hepatic glucose production.
• eGFR: Estimated glomerular filtration rate, a measure of kidney function.

Disclaimer

The information provided is for educational purposes only and reflects current knowledge as of the publication date. It does not constitute medical advice, recommendation for off-label use, or a substitute for a professional consultation. Always discuss medication choices, dosing, and potential interactions with a qualified healthcare practitioner. Our platform supplies general drug details; we do not dispense medication, prescribe, or guarantee availability. Use this guide responsibly and seek professional help for any health concerns.