Buy Jentadueto
jentadueto
$62.99
- Active ingredient: Linagliptin | Metformin Hydrochloride
- Category: Diabetes
- Delivery time: Airmail (14-21 days) | EMS trackable (5-9 days)
- Prescription: Included
- Availability: In Stock
Jentadueto XR 2.5/1000mg tablets are available to order from our Singapore pharmacy with reliable delivery. This combination medication works through dual action: linagliptin increases insulin production while metformin reduces glucose production and improves insulin sensitivity. Its extended-release formulation provides 24-hour blood sugar control with convenient once-daily dosing. It is an optimal solution for adults with type 2 diabetes who need comprehensive glucose management through combined mechanisms.
Table of contents
- Jentadueto Xr (Linagliptin; Metformin Hydrochloride) Buyer and Patient Handbook in Singapore
- What is Jentadueto Xr?
- Who Should Use Jentadueto Xr?
- How Does It Work?
- Why Choose Jentadueto Xr?
- Dosage, Administration, Lifestyle and Dietary Recommendations
- Recommended Dosage
- How to Take
- Missed Dose
- Overdose
- Special Populations
- Lifestyle & Diet
- Precautions and Warnings
- Drug Interactions
- Potential Side Effects
- Common Side Effects
- Less Common Side Effects
- Serious Side Effects
- Who Should Avoid This Medication?
- Storage Instructions
- Jentadueto Xr Alternatives
- Frequently Asked Questions
- How quickly will Jentadueto Xr lower my blood sugar?
- Can I take Jentadueto Xr if I’m on insulin?
- Is it safe to drink coffee while on this medication?
- Will I need regular blood tests?
- Does the tablet cause weight gain?
- What should I do if I experience persistent diarrhoea?
- Can I use this medication during my fasting month (Ramadan)?
- Is there any risk of hypoglycaemia if I skip a meal?
- Glossary
- Disclaimer
- How to purchase Jentadueto on our Website
- Reviews
- Write your review
Jentadueto Xr (Linagliptin; Metformin Hydrochloride) Buyer and Patient Handbook in Singapore
What is Jentadueto Xr?
Jentadueto Xr is a fixed-dose combination tablet that contains the DPP-4 inhibitor linagliptin (2.5 mg) and the biguanide Metformin hydrochloride (100 mg). It belongs to the diabetes therapeutic class and is indicated for adults with Type 2 Diabetes mellitus to improve blood-glucose control, especially when metformin alone does not achieve target levels. The product carries approvals from the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA) and Singapore’s Health Sciences Authority (HSA). It is supplied as a standard oral pill.
Who Should Use Jentadueto Xr?
- Adults (≥ 18 years) diagnosed with type 2 diabetes
- Patients whose blood glucose remains above target despite metformin monotherapy
- Individuals seeking to simplify their regimen by reducing pill burden
- Those with preserved renal function (eGFR ≥ 30 mL/min/1.73 m²) and no history of lactic acidosis
How Does It Work?
Linagliptin blocks the enzyme dipeptidyl-peptidase-4, which normally degrades the incretin hormones GLP-1 and GIP. Higher incretin levels stimulate the pancreas to release more insulin after meals and suppress glucagon, lowering post-prandial glucose. Metformin primarily reduces hepatic glucose production and improves peripheral insulin sensitivity, helping to lower fasting glucose. Together, the two agents address different pathways of glucose regulation, providing a more balanced glycaemic effect. There is no abuse potential associated with either component.
Why Choose Jentadueto Xr?
- Convenience: One tablet replaces separate linagliptin and metformin pills, supporting better adherence.
- Proven quality: The brand formulation meets stringent bio-equivalence standards and is manufactured under Good Manufacturing Practice (GMP).
- Cost-effectiveness: While a branded product, it may be covered by local insurance schemes; generic equivalents (linagliptin + metformin) are also available for price-sensitive patients.
- Off-label use (e.g., in gestational diabetes) is not recommended without specialist guidance.
Dosage, Administration, Lifestyle and Dietary Recommendations
Recommended Dosage
- 1 tablet (2.5 mg/100 mg) taken once daily with the main meal of the day.
How to Take
- Swallow the tablet whole; do not crush or chew.
- Take it with a full glass of water (≈ 200 mL).
- Administer with breakfast, lunch, or dinner - consistency helps minimise gastrointestinal upset.
Missed Dose
- If you remember within 12 hours, take the missed tablet with the next meal.
- If more than 12 hours have passed, skip it and resume the regular schedule; do not double-dose.
Overdose
- Seek immediate medical attention or call Singapore’s emergency number 995.
- Symptoms may include severe Nausea, Vomiting, abdominal Pain, or hypoglycaemia.
Special Populations
- Elderly: Start at the recommended dose; monitor renal function regularly.
- Renal impairment: Use only if eGFR ≥ 30 mL/min/1.73 m²; dose adjustment not required for linagliptin but metformin may need reduction.
- Hepatic disease: Avoid if there is severe hepatic insufficiency.
- Pregnancy & lactation: Not recommended unless the benefit outweighs risk; discuss with a specialist.
Lifestyle & Diet
- Avoid excessive alcohol ( > 14 units/week) as it raises the risk of lactic acidosis.
- Maintain a balanced diet rich in fibre, whole grains, and lean protein.
- Grapefruit has minimal interaction but large quantities of other citrus fruits may affect metformin absorption; keep intake moderate.
- Stay hydrated; dehydration can increase metformin-related risks.
Precautions and Warnings
- Lactic acidosis: Rare but serious; watch for unexplained Muscle Pain, breathing difficulty, or abdominal discomfort.
- Hypoglycaemia: More likely if combined with sulfonylureas or insulin; monitor blood glucose closely.
- Renal monitoring: Check eGFR at baseline, then at least annually.
- Hepatic monitoring: Assess liver enzymes if there is a history of liver disease.
- Allergy: Discontinue immediately if you develop rash, itching, or swelling of the face/tongue.
Drug Interactions
| Drug Class | Risk | Action |
|---|---|---|
| Sulfonylureas | Increased hypoglycaemia | Reduce sulfonylurea dose, monitor BG |
| Cimetidine | ↑ metformin levels | Consider dose reduction |
| Rifampicin | ↓ linagliptin exposure | Monitor glucose, adjust if needed |
| Contrast agents (iodinated) | ↑ risk of renal injury | Ensure adequate hydration, pause metformin before imaging |
Potential Side Effects
Common Side Effects
- Nausea
- Diarrhoea
- Stomach upset
- Headache
Less Common Side Effects
- Upper Respiratory Tract Infection
- Dizziness
- Metallic taste
Serious Side Effects
- Lactic acidosis: severe abdominal pain, rapid breathing, lethargy - call emergency services.
- Severe hypersensitivity: rash, blisters, facial swelling - stop medication and seek medical help.
- Pancreatitis: persistent upper-abdominal pain with vomiting - seek immediate attention.
Who Should Avoid This Medication?
- Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- Individuals with hepatitis or cirrhosis of the liver
- History of lactic acidosis while on metformin
- Known hypersensitivity to linagliptin, metformin, or any excipients
- Uncontrolled type 1 diabetes or diabetic ketoacidosis
Storage Instructions
- Keep below 30 °C; avoid damp or humid places.
- Store in the original blister pack to protect from moisture.
- Keep out of reach of children and pets.
- Do not refrigerate or freeze.
Jentadueto Xr Alternatives
| Name | Class | Key Difference |
|---|---|---|
| Generic Linagliptin/Metformin | DPP-4 + biguanide | Lower price, same dosage strength |
| Januvia + Glucophage | Separate pills | Two tablets; flexible dosing options |
| Tradjenta + Metformin | DPP-4 + biguanide | Different DPP-4 inhibitor (linagliptin vs. linagliptin) - comparable efficacy |
Frequently Asked Questions
How quickly will Jentadueto Xr lower my blood sugar?
Most patients observe a modest reduction in HbA1c (≈ .6-.9 %) after 12 weeks of consistent use.
Can I take Jentadueto Xr if I’m on insulin?
Yes, but dose adjustments may be necessary to avoid hypoglycaemia; regular glucose monitoring is essential.
Is it safe to drink coffee while on this medication?
Moderate caffeine intake (1-2 cups daily) does not interfere with the drug’s action.
Will I need regular blood tests?
Baseline kidney and liver function tests are recommended, then yearly or as advised by your healthcare professional.
Does the tablet cause weight gain?
Neither linagliptin nor metformin typically cause weight gain; some patients even experience modest weight loss.
What should I do if I experience persistent diarrhoea?
Contact a healthcare provider; they may suggest dose titration or switching to an extended-release formulation.
Can I use this medication during my fasting month (Ramadan)?
Yes, but take the tablet with the pre-dawn (Suhoor) or sunset (Iftar) meal to minimise gastrointestinal upset.
Is there any risk of hypoglycaemia if I skip a meal?
If you miss a meal, do not skip the tablet; instead, monitor glucose closely and consider a small snack.
Glossary
- DPP-4 inhibitor: A drug that blocks the enzyme responsible for breaking down incretin hormones, enhancing insulin release after meals.
- Metformin: The first-line oral agent for type 2 diabetes that lowers hepatic glucose production.
- eGFR: Estimated glomerular filtration rate, a measure of kidney function.
Disclaimer
The information provided is for educational purposes only and reflects current knowledge as of the publication date. It does not constitute medical advice, recommendation for off-label use, or a substitute for a professional consultation. Always discuss medication choices, dosing, and potential interactions with a qualified healthcare practitioner. Our platform supplies general drug details; we do not dispense medication, prescribe, or guarantee availability. Use this guide responsibly and seek professional help for any health concerns.
How to purchase Jentadueto on our Website
To purchase Jentadueto | Linagliptin on our website, just select the required dosage and quantity of pills above. The price of your choice will appear automatically. Next, add the chosen amount to your cart by clicking the Add to Cart button. You can either continue shopping for more pills or head to the checkout. At the Checkout, finalize your purchase through our secure payment gateway.
Jentadueto / Linagliptin pills are made using high-quality generic ingredients and are subject to strict quality control in line with WHO and Health Sciences Authority (HSA) standards. However, please note that Jentadueto pills are dispatched from outside Singapore due to prescriptions issued overseas.
Disclaimer: The content on this website is provided solely for informational purposes and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions or concerns regarding your health, and never disregard or delay seeking professional advice based on the information presented here. Use of this website does not create a doctor-patient relationship, and in the event of a medical emergency, please contact your local emergency services immediately. Our website assumes no responsibility or liability for any errors or omissions in the content provided.
Reviews
Been on Jentadueto XR for about 2 weeks now. The first few days were rough, honestly. Felt super bloated and had this weird metallic taste in my mouth. My doctor said it's the metformin, and it should pass. Trying to stick with it because my fasting sugar is already down from 9.5 to 7.2. Pro tip: take it right in the middle of a meal, not just before. Makes a huge difference for the stomach stuff.
My doc switched me to this from regular metformin because the GI issues were unbearable. Jentadueto XR is way gentler on my stomach, no more running to the bathroom after breakfast. But the trade-off is this constant, low-grade headache for the first month. It's manageable, but annoying. Also, you absolutely cannot miss a dose or take it late, or my sugar spikes like crazy the next day. It's effective, but you have to be super consistent.
Three years on this medication. It's kept my A1C below 6.5, which is the main thing. The key for me was figuring out the timing. I take it with my dinner around 7 PM. If I take it too late, I get really vivid, strange dreams. Another hack: drink a ton of water throughout the day, especially in this heat. If I get dehydrated, the leg cramps at night are brutal. It's a part of my life now, not a big deal.
It controls my blood sugar, no doubt. But the weight loss plateau is real. Lost the first 10kg, then nothing for 6 months. My endo says it's normal. The worst side effect for me is the dry mouth, especially at night. I keep a bottle of water by the bed. Found that sugar-free lozenges help. I wouldn't say I feel amazing, but I don't feel sick, and my numbers are good. It's a trade-off.
The linagliptin part is great, no issues. The metformin XR, though... even the extended release gives me gas if I eat too many carbs. I've learned to listen to my body. A small bowl of rice is okay, a large plate is a mistake. My advice: pair it with a low-carb diet, otherwise you're fighting the medication. On the plus side, my energy levels are much more stable throughout the day compared to before.
After 8 months, my skin got super itchy, especially on my arms and back. Not a rash, just unbearable itching. Doctor said it's a rare side effect but can happen with linagliptin. We added an antihistamine and it's mostly controlled now. It's frustrating because the medication works so well for my glucose. Just something to watch out for. Wouldn't have thought it was related until I read about it online.
Started this 4 days ago. The nausea is no joke. Felt like I was on a boat all day. My pharmacist said to try taking it with a spoonful of yogurt or peanut butter, something really substantial. It helped a bit. Also getting these weird 'brain zaps' when I turn my head quickly. Hoping this is just the adjustment period because I need to get my diabetes under control.
It works, but it's fragile. If I have even one beer, my sugar drops unexpectedly a few hours later. Learned that the hard way. Now I completely avoid alcohol. Also, be careful with ibuprofen or other NSAIDs. I took some for a backache and ended up with stomach pain. Stick to paracetamol. It's a good drug, but you have to play by its rules. No cheating.