Buy Glucovance
glucovance
$37.80
- Active ingredient: Metformin Glyburide
- Category: Diabetes
- Delivery time: Airmail (14-21 days) | EMS trackable (5-9 days)
- Prescription: Included
- Availability: In Stock
Glucovance, combining Metformin and Glyburide, is available from our Singapore pharmacy. This dual-action medication works by both decreasing liver glucose production and increasing insulin release from the pancreas, providing powerful blood sugar control. It is designed for adults with type 2 diabetes who may benefit from a combination therapy approach for more effective management of their condition.
Table of contents
- Glucovance (Metformin Glyburide) Buyer and Patient Handbook in Singapore
- What is Glucovance?
- Who Should Use Glucovance?
- How Does It Work?
- Why Choose Glucovance?
- Dosage, Administration, Lifestyle and Dietary Recommendations
- Recommended Dosage
- How to Take
- Missed Dose
- Overdose
- Special Populations
- Lifestyle & Diet
- Precautions and Warnings
- Drug Interactions
- Potential Side Effects
- Common Side Effects
- Less Common Side Effects
- Serious Side Effects
- Who Should Avoid This Medication?
- Storage Instructions
- Glucovance Alternatives
- Frequently Asked Questions
- How quickly does Glucovance lower blood sugar?
- Can I take Glucovance if I have a mild stomach ulcer?
- Is it safe to drink coffee while on Glucovance?
- What should I do if I feel dizzy after a dose?
- Can Glucovance be taken with other diabetes pills?
- Does Glucovance affect cholesterol levels?
- I missed several days of medication-can I restart?
- Will Glucovance cause weight gain?
- Glossary
- Disclaimer
- Glucovance Properties
- How to order Glucovance from our Pharmacy
- Reviews
- Write your review
Glucovance (Metformin Glyburide) Buyer and Patient Handbook in Singapore
What is Glucovance?
Glucovance is a combination oral medication containing Metformin and Glyburide, both of which belong to the biguanide and sulfonylurea classes respectively, used to improve blood-sugar control in adults with Type 2 Diabetes. It is approved by the FDA, EMA and the Health Sciences Authority (HSA) of Singapore. The drug is supplied as a tablet for oral administration.
Who Should Use Glucovance?
- Adults (≥ 18 years) diagnosed with type 2 diabetes who need additional glycemic control beyond diet, exercise, or monotherapy.
- Patients whose A1C remains above target despite metformin alone.
- Individuals with stable renal function (eGFR ≥ 30 mL/min/1.73 m²).
How Does It Work?
Glucovance combines two complementary mechanisms:
- Metformin reduces glucose production by the liver and improves insulin sensitivity in muscle.
- Glyburide stimulates the pancreas to release more insulin.
Together they lower fasting and post-prandial blood glucose, helping to maintain a more stable glucose profile. The medication does not cause euphoria or a “high,” but users should be aware of the risk of hypoglycaemia, especially if meals are missed.
Why Choose Glucovance?
- Convenient dual therapy: One pill replaces two separate tablets, simplifying daily routines.
- Proven efficacy: Clinical trials show greater A1C reduction compared with metformin alone.
- Cost-effective: Brand-name Glucovance is widely available in Singapore, with generic equivalents (metformin + glyburide) offering cheaper options for those with budget concerns.
Off-label uses (e.g., gestational diabetes) should only be considered after thorough discussion with a qualified healthcare professional.
Dosage, Administration, Lifestyle and Dietary Recommendations
Recommended Dosage
| Strength | Typical Dose |
|---|---|
| 400 mg/2.5 mg | 1 tablet once daily |
| 500 mg/5 mg | 1 tablet once daily |
The exact dose is tailored by the prescriber based on glycaemic targets and tolerability.
How to Take
- Swallow the tablet whole with a full glass of water.
- Take with the first main meal of the day to minimise gastrointestinal upset.
- Do not crush or split the tablet.
Missed Dose
If you remember within 12 hours, take the missed tablet with the next meal. Skip it if it’s been longer than 12 hours to avoid double dosing.
Overdose
Call emergency services (995 in Singapore) immediately. Symptoms may include severe Nausea, Vomiting, rapid breathing, or loss of consciousness. Provide the exact amount taken if known.
Special Populations
- Elderly: Start at the lowest strength (400 mg/2.5 mg) and monitor renal function closely.
- Renal impairment: Adjust dose or avoid if eGFR < 30 mL/min/1.73 m².
- Pregnancy & lactation: Use only if benefits clearly outweigh risks; discuss with a clinician.
Lifestyle & Diet
- Grapefruit: Avoid large amounts as it may increase glyburide levels.
- Alcohol: Limit intake; excessive drinking can heighten hypoglycaemia risk.
- Maintain regular physical activity and a balanced diet to complement medication effects.
Precautions and Warnings
- Monitor blood glucose regularly, especially when initiating therapy.
- Watch for signs of hypoglycaemia (dizziness, sweating, trembling).
- Metformin may cause lactic acidosis in rare cases; seek urgent care if you develop unexplained Muscle Pain, rapid breathing, or abdominal discomfort.
- Do not use if you have a known allergy to either component.
Drug Interactions
| Interacting Drug Class | Risk | Management |
|---|---|---|
| CYP2C9 inhibitors (e.g., fluconazole) | ↑ glyburide levels → hypoglycaemia | Dose reduction or close glucose monitoring |
| IV contrast agents | ↑ lactic acidosis risk (metformin) | Hold metformin 48 h before and after procedure |
| Beta-blockers | Mask hypoglycaemia symptoms | Frequent glucose checks; adjust dose if needed |
Potential Side Effects
Common Side Effects
- Nausea or mild stomach upset
- Diarrhoea
- Slight weight gain
Less Common Side Effects
- Skin rash or itching
- Metallic taste
Serious Side Effects
- Lactic acidosis (rare) - sudden muscle Pain, rapid breathing, abdominal discomfort; seek medical help immediately.
- Severe hypoglycaemia - confusion, loss of consciousness; treat with fast-acting glucose and call emergency services.
Who Should Avoid This Medication?
- Individuals with a known hypersensitivity to metformin, glyburide, or any excipients.
- Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²).
- Those with a history of lactic acidosis.
- Pregnant women not advised by a clinician.
Storage Instructions
- Keep tablets in the original container, tightly closed.
- Store at room temperature (15-30 °C), away from excess heat, moisture, and direct sunlight.
- Keep out of reach of children and pets.
Glucovance Alternatives
| Name | Class | Key Difference |
|---|---|---|
| Metformin + Glyburide (generic) | Biguanide + Sulfonylurea | Lower cost, same active ingredients |
| Metformin + Glipizide | Biguanide + Sulfonylurea | Different sulfonylurea; may have lower hypoglycaemia risk |
| Metformin + DPP-4 inhibitor | Biguanide + Incretin enhancer | No sulfonylurea-related hypoglycaemia; higher price |
Frequently Asked Questions
How quickly does Glucovance lower blood sugar?
Glucovance begins to lower glucose within a few days, but full effect on A1C may take 6-8 weeks.
Can I take Glucovance if I have a mild stomach ulcer?
Metformin can irritate the gastrointestinal lining; discuss with your clinician who may suggest a lower dose or gastro-protective strategies.
Is it safe to drink coffee while on Glucovance?
Moderate coffee consumption does not interfere with the medication’s action.
What should I do if I feel dizzy after a dose?
Dizziness may signal hypoglycaemia; check your blood glucose and, if low, consume fast-acting carbohydrates.
Can Glucovance be taken with other diabetes pills?
Usually not recommended without a clinician’s guidance, as it may increase hypoglycaemia risk.
Does Glucovance affect cholesterol levels?
Metformin may modestly improve lipid profiles, but Glucovance is not intended for Cholesterol Management.
I missed several days of medication-can I restart?
Resume at the lowest dose (400 mg/2.5 mg) and increase gradually, monitoring glucose closely.
Will Glucovance cause weight gain?
Glyburide can cause mild weight gain; lifestyle measures help mitigate this effect.
Glossary
- A1C: A blood test measuring average glucose over the past 2-3 months.
- eGFR: Estimated glomerular filtration rate, indicating kidney function.
- Hypoglycaemia: Low blood sugar, typically < 70 mg/dL, causing symptoms like shakiness and sweating.
Disclaimer
The information presented here is for general educational purposes only and does not replace professional medical advice. Off-label uses should be discussed with a qualified healthcare provider. Always consult your doctor or pharmacist before starting, stopping, or changing any medication. Our service provides access to licensed pharmacies in Singapore; users are responsible for ensuring the medication is appropriate for their personal health needs.
Glucovance Properties
- Original Manufacturer: Bristol-Myers Squibb
- Clinical use: Used for the treatment of type 2 diabetes.
- Spectrum of activity: Antidiabetic combination
- Mechanism of action: Combines metformin's insulin sensitivity improvement with glyburide's insulin secretion stimulation.
- Classification: Antidiabetic combination
- Recommended Dosage: 500 mg metformin and 2.5 mg glyburide once daily, increasing as needed.
- Basic Side Effects: Diarrhea, Nausea
- Moderate Side Effects: Hypoglycemia, Abdominal pain
- Serious Side Effects: Severe cases of lactic acidosis
How to order Glucovance from our Pharmacy
To order Glucovance | Metformin Glyburide on our online pharmacy, all you need to do is select the required dosage and quantity of pills above. The cost of the selected pack will appear automatically. Next, add the chosen amount to your cart by clicking the Add to Cart button. You can either continue shopping for more medications or head to the checkout. At the Checkout, finalize your purchase through our secure payment gateway.
Glucovance / Metformin-glyburide pills are made using high-quality generic ingredients and are subject to strict quality control in line with WHO and Health Sciences Authority (HSA) standards. However, please note that Glucovance pills are dispatched from outside Singapore due to prescriptions issued overseas.
Disclaimer: The content on this website is provided solely for informational purposes and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions or concerns regarding your health, and never disregard or delay seeking professional advice based on the information presented here. Use of this website does not create a doctor-patient relationship, and in the event of a medical emergency, please contact your local emergency services immediately. Our website assumes no responsibility or liability for any errors or omissions in the content provided.
Reviews
Been on Glucovance 500/5mg for 3 weeks now. The first week was brutal with nausea and some dizziness, but my fasting sugar dropped from 180 to 115. I snack on a plain cracker before taking it and that helps a lot. Stomach still feels a bit off sometimes.
My doctor switched me to this after metformin alone wasn't cutting it. Sugar levels are much more stable, no more crazy spikes after meals. But I have to be really careful about low sugar now. Always keep biscuits in my bag. The key is taking it exactly 30 minutes before lunch and dinner.
Five years on this med. It works, but the glyburide part makes me gain some weight which is frustrating. I've learned to never, ever take it on an empty stomach or it's a day ruined. My hack is a small bowl of plain oats or yogurt first thing.
The 400/2.5mg dose keeps my HbA1c in check, but the fatigue in the afternoons is real. I started taking my second pill right after dinner instead of before bed and it's helped a bit. Also, drinking lots of water is non-negotiable.
It controls my sugar well, but it completely killed my appetite. I have to force myself to eat small meals throughout the day. On the plus side, I lost a few kilos. Just have to watch out for weakness if I don't eat enough.
This medication is sensitive to alcohol. Learned that the hard way at a wedding. Even one beer made me feel awful. Now I just avoid it completely. Sugar numbers are good, but my social life took a hit.
Good for diabetes, bad for my stomach. Had to switch to the extended-release version of metformin-only, Glucovance was too harsh. The glyburide gave me a few scary low sugar episodes too. Just wasn't for me.
My HbA1c went from 9.5 to 6.8 in 6 months with Glucovance 500/5mg and diet changes. The initial side effects were tough, but they faded after a month. I take it with my biggest meals and always have a banana handy just in case.