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Aczone (Diaminodiphenyl Sulfone) Buyer and Patient Handbook in Singapore

What is Aczone?

Aczone is a 100 mg oral tablet containing the active ingredient diaminodiphenyl sulfone, marketed for the management of certain skin-related conditions. It belongs to the anti-inflammatory/antimicrobial class used primarily in dermatology. The product is approved by the Health Sciences Authority (HSA) of Singapore and complies with local safety standards.

Who Should Use Aczone?

• Adults diagnosed with the indicated skin condition (e.g., inflammatory Acne).
• Patients who have not responded adequately to topical therapies alone.
• Individuals without a history of severe hypersensitivity to sulfone drugs.

How Does It Work?

Aczone interferes with the growth of skin bacteria and reduces inflammatory responses by inhibiting neutrophil chemotaxis. Think of it as turning down the volume on an overactive immune alarm that fuels lesions. It does not have central nervous system effects, so it carries a low risk of abuse.

Why Choose Aczone?

• Consistency: Oral delivery provides steady drug levels compared with intermittent topical use.
• Convenience: One daily tablet fits easily into most routines.
• Clinical data: Trials have shown significant reduction in lesion count within 8-12 weeks.

(Off-label uses exist but require professional discussion before starting.)

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 100 mg once daily with water, preferably in the morning.

How to Take

• Swallow the tablet whole; do not crush or chew.
• Take with a light meal to minimise stomach upset.

Missed Dose

• If you remember within 4 hours, take it now.
• If it’s later in the day, skip and resume the regular schedule; do not double-dose.

Overdose

• Seek emergency medical care immediately.
• If possible, bring the tablet pack to assist clinicians.

Special Populations

• Elderly: May need monitoring of kidney function.
• Renal impairment: Dose adjustment may be required; consult a pharmacist.
• Pregnancy & breastfeeding: Use only if the benefit outweighs potential risk; discuss with a healthcare professional.

Lifestyle & Diet

• Avoid excessive alcohol as it may increase skin irritation.
• Grapefruit juice can affect drug metabolism; limit intake.
• Maintain a gentle skin-care routine; avoid harsh scrubs while on treatment.

Precautions and Warnings

• Do not use if you have a known allergy to sulfone compounds.
• Monitor for signs of hemolysis, especially if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Report any new rash, fever, or jaundice promptly.

Drug Interactions

Potential Side Effects

Common Side Effects

• Mild Nausea
• Headache
• Transient skin redness

Less Common Side Effects

• Dizziness
• Muscle aches
• Slight increase in liver enzymes

Serious Side Effects

• Severe skin reactions (e.g., Stevens-Johnson syndrome) - stop the medication and seek urgent care
• Hemolytic anemia - watch for dark urine or Fatigue

Who Should Avoid This Medication?

• Individuals with a documented sulfone allergy.
• Patients with severe G6PD deficiency.
• Those experiencing active severe infections that require alternative therapy.

Storage Instructions

• Keep tablets below 30 °C, away from direct sunlight.
• Store in a tightly closed container, out of reach of children.
• Do not use after the expiry date printed on the pack.

Aczone Alternatives

Frequently Asked Questions

How long before I see results?

Most patients notice improvement within 4-6 weeks, with maximal benefit around 3 months.

Can I drink coffee while taking Aczone?

Yes, moderate coffee intake does not affect Aczone’s efficacy.

Is it safe to consume alcohol?

Occasional alcohol is acceptable, but excessive drinking may increase skin irritation and liver strain.

What if I experience a rash?

Stop the medication and contact a healthcare professional immediately; a rash could signal a serious reaction.

Can I take Aczone with my blood pressure pills?

Generally safe, but monitor blood pressure because some antihypertensives may interact modestly.

Do I need to get blood tests while on Aczone?

Baseline liver and kidney function tests are recommended; repeat testing is advised if you have underlying organ issues.

Is Aczone suitable for teenagers?

Aczone is approved for adults; use in adolescents should be guided by a dermatologist.

What should I do if I forget a dose for more than 24 hours?

Contact a pharmacist or physician for advice; a longer gap may require re-evaluation of treatment effectiveness.

Glossary

• Sulfone: A class of compounds that reduce inflammation and bacterial growth on the skin.
• G6PD deficiency: A hereditary enzyme deficiency that can cause red blood cell breakdown when exposed to certain drugs.
• Hemolysis: The destruction of red blood cells, leading to anemia and related symptoms.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Off-label uses should be discussed with a qualified healthcare provider. Always read the patient information leaflet and consult a doctor or pharmacist before starting, stopping, or changing any medication. This handbook reflects the services offered through our online pharmacy platform in Singapore; users remain responsible for compliance with local regulations and personal health decisions.