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Imuran (Azathioprine) Buyer and Patient Handbook in Singapore

What is Imuran?

Imuran (Azathioprine) is a muscle-relaxant drug whose active ingredient, azathioprine, works as an immunosuppressant. It is prescribed to help control autoimmune conditions such as Rheumatoid Arthritis and Inflammatory Bowel Disease. The medication is approved by the Health Sciences Authority (HSA) of Singapore and is supplied in oral pill form.

Who Should Use Imuran?

• Adults diagnosed with autoimmune disorders requiring long-term immune modulation
• Patients who have not responded adequately to first-line therapies
• Individuals who need a steroid-sparing option under specialist supervision

How Does It Work?

Azathioprine interferes with the synthesis of DNA in rapidly dividing immune cells, reducing the body’s overactive immune response. Think of it as temporarily dimming the engine of a car that is revving too high; the underlying system continues to run, but at a calmer pace. Because it suppresses immunity, the drug should be used only under medical guidance and not for recreational purposes.

Why Choose Imuran?

• Proven efficacy for several chronic autoimmune diseases
• Available as a generic product, offering cost savings compared with branded options
• Well-studied safety profile when monitored regularly

Off-label uses exist, but they should only be considered after discussing the risks and benefits with a qualified healthcare professional.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• Typical starting dose: 25 mg once daily
• May be increased to 50 mg once daily based on clinical response

How to Take

• Swallow the pill whole with a full glass of water.
• Can be taken with or without food; consistency helps maintain steady blood levels.

Missed Dose

• If you remember within 12 hours, take the missed dose.
• If it is longer than 12 hours, skip it and resume your regular schedule.

Overdose

• Seek emergency medical attention immediately.
• Provide the exact amount taken and the time of ingestion.

Special Populations

• Elderly: Start at the lower end (25 mg) and monitor blood counts closely.
• Renal impairment: Dose may need reduction; specialist review required.
• Pregnancy & lactation: Use only if benefits outweigh potential risks; discuss with your doctor.

Lifestyle & Diet

• Avoid excessive alcohol, which can increase liver toxicity.
• No known interaction with grapefruit, but maintain a balanced diet.

Precautions and Warnings

• Regular blood tests (CBC, liver function) are essential to detect early toxicity.
• Do not vaccinate with live vaccines while on Imuran.
• Report signs of infection (fever, sore throat) promptly.

Drug Interactions

Potential Side Effects

Common Side Effects

• Nausea
• Mild Hair Loss
• Transient fever

Less Common Side Effects

• Elevated liver enzymes
• Decreased white-blood-cell count
• Rash or itching

Serious Side Effects

• Severe infection (e.g., Pneumonia) - seek medical help immediately
• Unexplained bruising or bleeding - consult a doctor
• Persistent abdominal Pain - evaluate for liver issues

Who Should Avoid This Medication?

• Patients with known hypersensitivity to azathioprine or any component of the pill
• Individuals with severe liver disease (e.g., cirrhosis)
• Patients currently receiving live attenuated vaccines

Storage Instructions

• Keep at room temperature (15-30 °C).
• Store in a dry place away from direct sunlight.
• Keep out of reach of children and pets.

Imuran Alternatives

Frequently Asked Questions

How long does it take for Imuran to start working?

Most patients notice an improvement in symptoms after 4-6 weeks of consistent therapy.

Can I drink coffee while taking Imuran?

Yes, moderate coffee consumption does not affect Imuran’s efficacy.

Is it safe to exercise while on Imuran?

Regular, moderate exercise is fine; however, avoid high-intensity workouts if you develop Fatigue or infections.

What should I do if I develop a fever?

Contact a healthcare professional promptly, as fever may signal an infection that needs early treatment.

Can I take Imuran with my regular vitamins?

Most vitamins are safe, but avoid high-dose folic acid without medical advice.

Does Imuran affect my ability to drive?

Generally no, unless you experience dizziness or severe fatigue; in that case, refrain from driving.

How often will I need blood tests?

Initially every 2-4 weeks, then every 3-6 months once stable, as directed by your clinician.

Can Imuran be stopped abruptly?

Do not stop suddenly; tapering under medical supervision is required to avoid disease flare-ups.

Glossary

• Immunosuppressant: A drug that reduces the activity of the immune system.
• Hematologic: Relating to blood cells; important for monitoring side effects.
• Tapering: Gradually decreasing a medication dose to prevent withdrawal effects.

Disclaimer

The information provided here is for general educational purposes only and does not replace professional medical advice. Imuran may be used off-label only after thorough discussion with a qualified healthcare provider. Our service offers a convenient platform to purchase approved medicines, but the ultimate responsibility for safe and appropriate use rests with the individual user. Always consult a licensed practitioner before starting, changing, or stopping any medication.