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Cycrin (Medroxyprogesterone) Buyer and Patient Handbook in Singapore

What is Cycrin?

Cycrin contains medroxyprogesterone, a synthetic progestogen used in women's health. It is prescribed for hormone replacement therapy, menstrual disorders, and prevention of endometrial hyperplasia. Cycrin is available as oral tablets and has been approved by the Health Sciences Authority (HSA) in Singapore.

Who Should Use Cycrin?

• Women requiring Progesterone support during menopause or Hormone Therapy.
• Patients with irregular or heavy menstrual bleeding not controlled by other measures.
• Women using estrogen therapy who need protection against endometrial over-growth.

How Does It Work?

Medroxyprogesterone mimics the natural hormone progesterone, binding to progesterone receptors in the uterus and other tissues. This action stabilises the endometrial lining, reduces menstrual blood loss and supports the hormonal balance needed during menopause. The drug does not produce a “high” and has no abuse potential.

Why Choose Cycrin?

Cycrin offers a reliable, well-studied progestogen option with consistent tablet strength. As a branded product, it provides quality assurance, while generic medroxyprogesterone tablets are also available for cost-conscious patients.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 5 mg tablet - usually one tablet daily.
• 10 mg tablet - typically one tablet daily for stronger hormonal needs.

How to Take

• Swallow the tablet whole with a full glass of water.
• Can be taken with or without food; consistency each day is preferred.

Missed Dose

• If you remember within 12 hours, take the missed tablet.
• If more than 12 hours have passed, skip it and resume the regular schedule. Do not double-dose.

Overdose

• Seek immediate medical attention or call the Singapore Poison Centre (180-222-2345).
• Symptoms may include Nausea, Vomiting, dizziness or abnormal bleeding.

Special Populations

• Elderly: Start with the lower 5 mg dose; monitor for fluid retention.
• Renal or hepatic impairment: Dose may need adjustment; consult a pharmacist.
• Pregnancy: Not indicated; avoid unless clearly prescribed for a specific obstetric indication.

Lifestyle & Diet

• No dietary restrictions, but avoid excessive grapefruit juice as it can alter drug metabolism.
• Alcohol does not affect efficacy, but excessive intake may increase side-effects like dizziness.

Precautions and Warnings

• Use only under medical supervision if you have a history of blood clots, liver disease, or hormone-sensitive cancers.
• Monitor blood pressure regularly; progesterone can cause fluid retention.
• Inform your healthcare provider of any recent surgeries or ongoing infections.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache
• Nausea or abdominal discomfort
• Breast tenderness

Less Common Side Effects

• Weight gain or fluid retention
• Mood changes or mild Depression
• Irregular spotting

Serious Side Effects

• Severe abdominal Pain or persistent vomiting - seek medical help
• Unusual bleeding or bruising - contact a healthcare professional
• Signs of blood clots (leg swelling, chest pain) - emergency care required

Who Should Avoid This Medication?

• Known hypersensitivity to medroxyprogesterone or any tablet excipients.
• Active hormone-sensitive malignancies (e.g., breast or Endometrial Cancer).
• Uncontrolled Hypertension or severe liver disease.

Storage Instructions

• Keep tablets in the original container, tightly closed.
• Store at 20-25 °C (68-77 °F); protect from moisture and light.
• Keep out of reach of children and pets.

Cycrin Alternatives

Frequently Asked Questions

How long does it take for Cycrin to start relieving heavy periods?

Most women notice improvement within 1-2 months of consistent daily use.

Can I take Cycrin while on estrogen replacement therapy?

Yes, Cycrin is often prescribed alongside estrogen to protect the uterine lining.

Does Cycrin affect my ability to become pregnant?

Cycrin can suppress ovulation; discuss family planning with your clinician if pregnancy is desired.

Is it safe to use Cycrin during a lactation period?

Medroxyprogesterone passes into breast milk in small amounts; consult a lactation specialist before use.

What should I do if I experience persistent spotting?

Report the symptom to your healthcare provider; dosage adjustment may be needed.

Can I take Cycrin with over-the-counter pain relievers?

Acetaminophen and ibuprofen are generally safe, but avoid chronic high-dose NSAIDs without medical advice.

Does grapefruit juice interfere with Cycrin?

Yes, large amounts can increase blood levels; limit grapefruit consumption.

How should I store the tablets when traveling abroad?

Carry them in a sealed container, keep them at room temperature, and avoid exposure to extreme heat or humidity.

Glossary

• Progestogen: A class of hormones that mimic natural progesterone, regulating the menstrual cycle and supporting pregnancy.
• Endometrial hyperplasia: Thickening of the uterine lining, which can increase the risk of Cancer if untreated.
• CYP3A4: An enzyme in the liver that metabolises many drugs; inhibitors can raise drug concentrations.

Disclaimer

The information provided here is for general educational purposes and does not replace professional medical advice. Cycrin may be used off-label only under the guidance of a qualified healthcare professional. Readers are responsible for consulting their own clinicians before starting, stopping, or modifying any medication. This handbook reflects services offered through our online pharmacy platform in Singapore; all transactions comply with local regulations.