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Aldactone (Spironolactone) Buyer and Patient Handbook - Singapore

What is Aldactone?

Aldactone is a potassium-sparing diuretic used primarily to treat fluid overload, High Blood Pressure, and certain cases of Heart Failure. It belongs to the class of aldosterone antagonists and is approved by the US FDA, EMA and Singapore’s HSA. The medication is supplied as oral tablets.

Who Should Use Aldactone?

• Adults with Hypertension or heart failure requiring fluid reduction
• Patients with Primary Hyperaldosteronism
• Individuals with oedema secondary to liver or Kidney Disease (under physician supervision)

How Does It Work?

Aldactone blocks the hormone aldosterone, which normally tells the kidneys to retain sodium and water. By blocking this signal, the drug promotes the excretion of excess fluid while sparing potassium. Think of it as turning off a faucet that’s been left running, helping the heart pump more efficiently. The medication has a low potential for abuse, but it should be taken only as directed.

Why Choose Aldactone?

• Generic advantage: Identical therapeutic effect to brand-name products at a lower cost.
• Proven track record: Over 50 years of clinical use worldwide.
• Off-label uses (e.g., Acne, Hirsutism) are possible but require a health-care professional’s guidance.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

• 25 mg once daily for mild fluid retention or hypertension
• 100 mg once daily for moderate-to-severe heart failure (dose may be titrated)

How to Take

• Swallow the tablet whole with a full glass of water.
• Can be taken with or without food; consistency each day helps maintain steady blood levels.

Missed Dose

• If you remember within 12 hours, take it now.
• If it’s been longer, skip the missed dose and resume your regular schedule. Do not double-dose.

Overdose

• Seek immediate medical help if you experience severe dizziness, fainting, or a rapid heartbeat. Call Singapore’s 995 emergency line.

Special Populations

• Elderly: Start with 25 mg; monitor kidney function and potassium.
• Renal impairment: Dose may need reduction; check labs regularly.
• Pregnancy & breastfeeding: Use only if benefits outweigh risks; discuss with a clinician.

Lifestyle & Diet

• Avoid large amounts of grapefruit or grapefruit juice, which can raise drug levels.
• Maintain adequate hydration; a balanced diet with normal potassium intake is recommended.

Precautions and Warnings

• Monitor blood pressure and serum potassium regularly.
• Do not use if you have hyperkalaemia, severe kidney disease, or anuria.
• Inform your clinician before starting any new medication or supplement.

Drug Interactions

Potential Side Effects

Common Side Effects

• Headache, dizziness, Fatigue, mild Nausea

Less Common Side Effects

• Breast tenderness, menstrual irregularities, mild rash

Serious Side Effects (seek medical help)

• Severe hyperkalaemia (muscle weakness, irregular heartbeat)
• Acute kidney injury
• Severe allergic reaction (swelling, breathing difficulty)

Who Should Avoid This Medication?

• Known hypersensitivity to spironolactone or any tablet component
• Severe hyperkalaemia or anuria
• End-stage renal disease without dialysis

Storage Instructions

• Store at 20-25 °C (68-77 °F) in a dry place.
• Keep the bottle tightly closed and out of reach of children.
• Do not freeze; discard after the expiry date.

Aldactone Alternatives

Frequently Asked Questions

How long does it take to feel the effect?

Most patients notice a reduction in swelling or blood pressure within 3-5 days, but full benefit may take 2-3 weeks.

Can I drink coffee or alcohol while on Aldactone?

Moderate coffee is fine, but limit alcohol as it can increase dizziness and affect blood pressure.

I’m not seeing any improvement-what should I do?

Contact your clinician; the dose may need adjustment or a different medication may be required.

Is it safe to take Aldactone with my blood pressure pill?

Many blood pressure drugs are compatible, but ACE inhibitors, ARBs, and potassium supplements require lab monitoring.

Can I take Aldactone during pregnancy?

Only if the benefit clearly outweighs the risk; discuss with a health professional.

Will it affect my cholesterol?

Aldactone does not directly change cholesterol levels.

Does it cause weight loss?

Fluid loss may lead to modest weight reduction, but it is not a weight-loss drug.

What should I do if I miss a dose for two days?

Resume the regular schedule; do not double-dose. If you’re unsure, contact a pharmacist.

Are there any foods I must avoid?

Limit high-potassium foods (e.g., bananas, oranges, tomatoes) if your potassium levels are high.

Glossary

• Aldosterone antagonist: A drug that blocks the hormone aldosterone, reducing sodium and water retention.
• Hyperkalaemia: Elevated potassium in the blood, which can affect heart rhythm.
• Bioequivalence: When a generic drug shows the same absorption and effect as the brand version.

Disclaimer

The information provided is for general educational purposes and does not replace professional medical advice. Off-label uses should be discussed with a qualified health-care provider. Our platform offers convenient access to approved medicines, but the ultimate responsibility for safe use rests with the patient and their clinician.